摘要
目的了解茶碱血药浓度监测的临床使用价值.方法分析我院资料齐全的909例茶碱血药浓度(质量浓度)监测结果及相应临床膊资料.结果①除服茶碱自杀的1例病人外,其余908例病人中,首次检测茶碱血药浓度在5～20μg/mL范围内668例,超过20μg/mL者76例,低于5μg/mL者164例.②血药浓度超过20μg/mL者可表现出不同程度的消化、循环、神经系统表现,甚至因此死亡,但也可无临床表现.停药后血药浓度降低速度存在很大差异.③在口服茶碱制剂基础上静脉注射茶碱易诱发茶碱中毒.结论监测茶碱血药浓度有助于保证茶碱合理使用、及时诊断和处理茶碱中毒.
Objective Evaluate clinical utilization of plasma theophylline concentration monitoring. Methods Plasma theophylline concentration monitoring materials of 909 patients and the relevant clinical manifestations were analyzed. Results ① Plasma theophylline concentrations were in the range of 5 - 20 μg/mL in 668 patients of 908 patients （ except one patient who committed suicide with theophylline）, surpassing 20 μmL in 76 patients, and lower than 5 μg/mL in 164 patients. ② Clinical manifestations in digestive, circulatory, and nervous systems and even death can be observed in patients with plasma theophylline concentration higher than 5 -20 μg/mL, or no clinical manifestation can be observed. The decreasing speed of plasma theophylline concentration after theophylline withdrawal is diversified significantly. ③Intravenous dripping of theophylline in addition to oral administration of theophylline tend to cause theophylline intoxication. Conclusion Plasma theophylline concentration monitoring can contribute to proper clinical utilization of theophylline, and diagnosis and treatment of theophylline intoxication.
出处
《广东药学院学报》
CAS
2005年第6期706-707,共2页
Academic Journal of Guangdong College of Pharmacy
关键词
茶碱
药物监测
血药浓度
theophylline
drug monitoring
plasma concentration
