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VEGF-D/VEGFR-3信号通路在声门上型喉癌淋巴转移过程中的作用 被引量：2

Effect of VEGF-D/VEGFR-3 signal pathway in the process of supraglottic carcinoma lymph metastasis
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摘要 目的:探讨VEGFD/VEGFR3信号通路在声门上型喉癌淋巴结转移过程中所起的调控作用。方法:应用RTPCR方法检测VEGFD及其受体VEGFR3在声门上型喉癌交界区癌组织、癌旁组织及正常喉黏膜组织的表达水平。结果:有淋巴转移组VEGFD及其受体VEGFR3癌组织表达分别为2.070±0.074和2.022±0.061,癌旁组织分别为1.129±0.067和1.131±0.068,正常喉黏膜组织分别为0.450±0.048和0.478±0.064;无淋巴转移组VEGFD及其受体VEGFR3癌组织表达分别为1.327±0.060和1.328±0.054,癌旁组织分别为0.927±0.052和0.917±0.061,正常喉黏膜分别为0.385±0.033和0.335±0.040;两组VEGFD及其受体VEGFR3表达均为癌组织高于癌旁组织高于正常喉黏膜组织,差异有统计学意义,t≥5.651,P<0.001。有淋巴转移组癌、癌旁组织二因子表达均高于无转移组,差异有统计学意义,t≥2.388,P<0.05;两组正常组织二因子表达差异无统计学意义,t≤1.873,P>0.05。结论:VEGFD/VEGFR3信号通路与声门上型喉癌淋巴结转移密切相关,二者在癌组织、癌旁组织的高表达有可能作为预测淋巴结转移的指标。VEGFD/VEGFR3通路将有望成为声门上型喉癌淋巴结转移预防和治疗的新靶点。 OBJECTIVE：To investigate the control effect of VEGF-D/VEGFR-3 signal pathway during the process of lymph metastasis. METHODS： The VEGF-D/VEGFR-3 level in carcinoma tissue, para-tumor tissue and normal tissue of 50 supraglottic carcinoma patients （25N0 cases, 25N＋ cases） was detected with reverse transcription polymerase chain reaction （RTPCR）, then analyze the law. RESULTS： In lymph metastasis group, the levels of VEGF-D and VEGFR-3 are 2.070± 0.074, 2. 022±0. 061 in carcinoma area, 1. 129±0. 067, 1. 131±0. 068 in para-tumor area, 0. 450±0. 048, 0. 478±0. 064 in normal area respectively. In non-lymph metastasis group, the levels of VEGF-D and VEGFR-3 are 1. 327 ±0. 060, 1. 328± 0. 054 in carcinoma area, 0. 927 ± 0. 052, 0. 917 ± 0. 061 in para-tumor area, 0. 385±0. 033, 0. 335± 0. 040 in normal area respectively. In the 2 groups, The highest level of VEGF-D and VEGFR- 3 is carcinoma tissue, then is para-tumor, then is normal tissue; the differences are significant, t≥5. 651, P〈0. 001. The differences of VEGF-D and VEGFR-3 level in carcinoma and paratumor areas between the 2 groups are significant, t≥2. 388,P〈 0. 05; in normal tissue are insignificant, t≤1. 873, P〉0.05. CONCLUSIOS： The VEGF-D/VEGFR-3 signal pathway is correlated with supraglottic carcinoma lymph metastasis. Their high expression in carcinoma and para-tumor may predict supraglottic carcinoma lymph metastasis. The pathway may become a new target of preventing and treating supraglottic carcinoma lymph metastasis.
作者 赵月皎 季文樾
机构地区 中国医科大学附属第一医院耳鼻喉科
出处 《肿瘤防治杂志》 2005年第22期1720-1724,共5页 China Journal of Cancer Prevention and Treatment
关键词 喉肿瘤/病理学 声门/病理学 血管内皮生长因子D 血管内皮生长因子受体3 淋巴转移 逆转录聚合酶链反应 laryngeal neoplasms/pathology glottis/pathology vascular endothelial growth factor D vascular endothelial growth factor receptor 3 lymphatic metastasis reverse transcriptase polymerase chain reaction
分类号 R739.6 [医药卫生—肿瘤]
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参考文献15

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二级参考文献7

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共引文献7

同被引文献35

  • 1王宗贵,金春顺,李野,赵明,魏显艳.喉癌中血管内皮生长因子C与淋巴转移的关系[J].中国免疫学杂志,2007,23(1):82-84. 被引量：8
  • 2王晓蕾,刘宝全,李雪梅,李天开,张雅芳.人喉癌组织中VEGF-C、VEGF-D及其受体3的表达及意义[J].解剖科学进展,2007,13(2):100-103. 被引量：7
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引证文献2

二级引证文献3

肿瘤防治杂志
2005年 第22期

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