摘要
目的:探讨中西医结合治疗消化性溃疡(PU)的临床疗效及机制.方法:将PU患者120例随机分为6组,另选10个经内镜证实无PU,但有消化道症状者为对照组.在用药1个月后观察临床疗效.结果:健胃愈疡颗粒+雷尼替丁胶囊治疗消化性溃疡在临床证候及症状改善方面优于雷尼替丁胶囊(P＜0.01～0.05);健胃愈疡颗粒+雷尼替丁胶囊、健胃愈疡颗粒、雷尼替丁胶囊在治疗溃疡愈合率、Hp清除率方面无显著差异(P＞0.05).健胃愈疡颗粒+雷尼替丁胶囊治疗消化性溃疡可显著上调胃黏膜MUC5AC mRNA的表达(P＜0.01);下调ETAR(内皮素-1A受体) mRNA的表达(P＜0.01).结论:健胃愈疡颗粒+雷尼替丁胶囊治疗PU具有明显优势,其治疗机制可能是上调MUC5AC mRNA的表达改善胃黏膜黏蛋白屏障保护作用,下调ETAR mRNA的表达改善胃黏膜血流.
Objective To explore the therapeutic effects and mechanisms of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers. Methods One hundred and twenty patients were randomly divided into 6 groups. Another 10 patients as the control group were confirmed with no peptic ulcers by endoscope, but had digestive tract symptoms. The clinical effects were compared among each group after the one month treatment. Results The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome （P 〈 0.01 to 0.05）, but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules （P 〉 bination of Jianweiyuyang granules and ranitidine capsules could significantly upregulate MUCSAC mRNA （P 〈0.01 ） , while downregulate the expression of ETAR mRNA （P 〈 0.05 ）. The come expression of（P〈0.01）. Conclusion There is obvious advantage in treating peptic ulcers by the combination of Jianweiyuyang granules and ranitidine capsules, and its mechanisms may be to protect the gastric mucosal barrier by up-regulating the expression of MUC5AC mRNA and to improve the gastric mucosal blood flow by down-regulating the expression of ETAR mRNA.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2005年第6期714-718,共5页
Journal of Central South University ：Medical Science
基金
湖南自然科学基金(01JJY2135)
关键词
消化性溃疡
中西医结合治疗
疗效
MUC5AC
ETAR
peptic ulcer
therapy of combination of traditional Chinese medicine and western medicine
therapeutic effect
MUCSAC
ETAR
