摘要
目的:帕金森病是一种60岁以后迅速增加的进行性神经变性病。在疾病后期会出现运动波动、僵直、幻觉和痴呆等许多并发症,针对这些临床问题,阐述帕金森病的药物治疗效果概况。资料来源:应用计算机检索medline1997-01/2005-04关于帕金森病治疗方面的英文文章。检索词为“Parkinsondisease,treatment”。资料选择:对资料进行初审,选取包括实验组和对照组的文献,去除重复性试验研究和较旧的文献。然后查阅全文。资料提炼:共收集到280篇关于帕金森病治疗方面的文章,从中选取关于药物治疗方面的25篇。资料综合:将资料按治疗目的和药物种类进行分类综合。①治疗帕金森病的药物有七大类,需要根据患者的具体情况艺术性地选择药物治疗。②多巴胺受体激动剂、左旋多巴、单胺氧化酶抑制剂都可作为首选药物开始治疗。③当出现症状波动时可选择儿茶酚氧位甲基转移酶抑制剂或单胺氧化酶抑制剂治疗,均可使患者的运动功能改善,并可减少左旋多巴用量。④当有非运动症状如幻觉、错觉等精神症状出现时,要考虑给予改善精神症状又不影响肢体运动的药物。结论:目前治疗帕金森病合并认知功能减退的药物还很少,有待于进一步研究和可发。
OBJECTIVE：Parkinson disease, is a progressive neural degenerative disease that increases sharply after the sixth decade.Many complications such as motor fluctuations, dyskinesia, hallucination and demantia, etc,oeeur at late stage of Parkinson disease.Along these clinical problems,to explain the outline of effect of drug treatment on Parkinson disease.
DATA SOURCES：Using the key terms “Parkinson disease, treatment”, we searched the medline for the articles on therapy of Parkinson disease published between January 1997 and April 2005 in English.
STUDY SELECTION：All articles were selected firstly,and those including experimental and control group were collected.Repeated articles or older studies were excluded, and then looked up the full texts.
DATA EXTRACTION：A total of 280 articles about treatment of Parkinson disease were searched, twenty-five studies about drug-treatment were collected.
DATA SYNTHESIS：According to purpose of treatment and drug category, these articles were classified. （1） There were 7 kinds of drugs for treating Parkinson disease.The detailed condition of the patients needed to be considered so as to choose drug artistically. （2） Dopamine receptor agonists, bendopa and monoamine oxidase inhibitor （MAOI） could be used as the first selected drug to treat. （3）When occurred symptom fluctuation,the catechol-omethyltransfera.（COMT） inhibitor or MAOI could be selected, which could improve the motor function of patients and reduce the dosage of bendopa. （4） When hallucination and deception, etc. appeared, the drug that could improve psychiatric symptom but not had effect on limb movement.
CONCLUSION：The therapy for troating Parkinson disease integrating with cognitive hypofunction is little. It will be further explored.
出处
《中国临床康复》
CSCD
北大核心
2005年第45期104-106,共3页
Chinese Journal of Clinical Rehabilitation
