摘要
目的探讨胃安素对胃粘膜的保护作用。方法动物实验:将动物随机分为正常对照组、无水乙醇对照组及胃安素预防组。实验前禁食24h,禁水2h,分别以 N.S1ml,N.S1ml 及胃安素1ml 灌胃,2h 后再分别以 N.S1ml,无水乙醇1ml 及无水乙醇1ml 灌胃。再过2h 后麻醉,抽血,处死取胃。进行大体、光镜、电镜观察,检测胃粘膜Na^+ -K^+ -ATPase 活性、胃酸及血浆内皮素、前列腺素。临床研究:胃安素组及雷尼替丁组均为胃溃疡患者,分别口服胃安素30mg,雷尼替丁150mg,2次/d,共4周。治疗前及治疗后随访症状、体征、不良反应,并作血尿常规、肝肾功能及内镜检查。结果胃安素能增强胃粘膜 Na^+-K^+-ATPase 活力,增加胃粘膜前列腺素合成及降低血浆内皮素,但不影响胃酸分泌。胃安素组大鼠的胃粘膜损伤较无水乙醇组明显减轻。胃安素治疗胃溃疡的效果略优于雷尼替丁。结论胃安素有明显的胃粘膜保护作用。
AIMS To study the protective effect of thymus on gastric mucosa. METHODS Experiment in rats:We divided the rats into normal saline control group(NSCG)absolute alcohol control group(AACG)and thy- mus treatment group(TTG)at random.All rats were fasted for 24 hrs and deprivated of water for 2 hrs before the experiment.First 1 ml of normal saline(NSCG and AACG)or 1 ml of oral solution of thymus (TTG)was given.After two hours 1 ml of normal saline(NSCG)or 1 ml of absolute alcohol(AACG and TTG)was given.After another two hours all rats were anesthetized.Hemospasia was followed then we killed the rats and took their stomaches out.We observed the gas- tric mucosa by macroscopy,optical microscope and electron micro- scope and detected Na^+-K^+-ATPase of gastric mucosa,homogenate, gastric acid,endothelin(ET)and prostaglandin(PG)in plasma.Clinic control study:All patients suffered from gastric ulcer 30 mg of thymus (thymus treatment group)or 150 mg of ranitidine(ranitidine treat- ment group)was given ig twice a day for four weeks.The patients were followed up before treatment and after treatment.The symptom,sign and adverse reaction were recorded.The blood urine routine,liver lenal redal function examination and gastroscopy were given at the same time. RESULTS Thymus could enhance the vitality of Na(+)K(+)-ATPase increase PG level and reduce ET level in plasma but it could do nothing on the secreting of gastric acid.The gastric mucosal injury of TTG was obviously lighter than that of AACG.The treatment effect of thymus was slightly better than that of ranitidine. CONCLUSIONS Thymus has obvious protective effect on gastric mucosa.
关键词
胃安素
胃粘膜损伤
药理学
gastric mucosa
endothelin
Na^+-K^+-ATPase
prostaglandin
Ranifidise
thymus
