摘要
以对甲氧乙基苯酚和环氧氯丙烷为原料,强碱KOH为催化剂,PEG400(聚乙二醇400)为相转移催化剂,通过醚化反应和胺化反应合成了美多心安。本工艺路线简单,原料易得,反应的整体收率达到50%。研究了不同反应条件对反应的影响。对中间体和目标产物进行了IR、1HNMR、HPLC定性定量分析。确定了较好的合成反应条件。
This paper has studied strong alkali catalyst KOH and phase transfer catalyst PEG400 in synthesizing Metoprolol by 4 - （2 - methoxy - ethyl） phenol and epichlorohydrin by etherification reaction and amination reaction. The technics of the synthesis is original , the raw materials were easy to be acquired, the route is easy, The yield of product is 50%. The effects of differents reaction conditions were studied. The composition of intermediate and products were examined by IR and 1HNMR method. The appropriate reaction condition were established.
出处
《南昌大学学报（理科版）》
CAS
北大核心
2005年第6期529-532,共4页
Journal of Nanchang University(Natural Science)
基金
江西省教育厅科技攻关项目(Z02292)
