摘要
目的探讨单纯骨转移瘤患者经放射性药物氯化89锶(89SrCl2)治疗后的免疫功能变化及其与疗效的关系。方法经临床确诊的、以骨转移瘤为首发症状患者25例,采用放射性药物89SrCl2治疗。选择20例体检正常者作为对照组。分别测定单纯骨转移瘤患者治疗前、后及对照组T淋巴细胞亚群CD4+、CD8+和CD4+/CD8+值,并比较有效组与无效组患者间免疫学指标变化。结果对照组CD4+、CD8+和CD4+/CD8+分别为(38.83±8.95)%、(32.19±8.51)%和1.29±0.47。单纯骨转移瘤患者治疗前CD4+、CD8+和CD4+/CD8+分别为(31.12±8.12)%、(41.75±10.91)%和0.84±0.22,治疗后分别为(36.21±8.71)%、(35.08±10.14)%和1.19±0.27。对照组与单纯骨转移瘤治疗前、单纯骨转移瘤治疗前与治疗后相比,差异有统计学意义(P<0.05)。根据疼痛得分,将单纯骨转移瘤患者分为治疗有效组和无效组。在治疗前,有效组与无效组的免疫指标差异无统计学意义(P>0.05);而治疗后,有效组CD4+、CD8+、CD4+/CD8+和病灶数分别为(37.81±5.18)%、(33.17±6.38)%、1.33±0.31和6.64±3.11(个),无效组分别为(32.09±5.72)%、(39.99±5.38)%、0.82±0.22和9.87±3.46(个),两组免疫指标差异有统计学意义(P<0.05),治疗有效组的病灶数减少程度明显好于无效组(P<0.05)。结论89SrCl2治疗后,骨转移瘤患者免疫功能得到恢复。
Objective To investigate the influence of ^89SrCl2 (strontium-89 chloride) on immune functions in patients with simple bone metastases. Methods Twenty-five patients diagnosed as simple bone metastases with un-detectable primary tumors were treated with s9 SrC12. The CI)4^+ , CD8 ^+ , CD4^+/CD8^+ lymphocyte subsets were assessed before and after ^89SrCl2 treatment. Twenty normal individuals served as controls. Results The CD4^+ , CD8^+ and CD4 ^+/CD8^+ in the control group were (38. 83 ± 8.95)% , (32.19 ±8.51) % and 1.29 ±0.47, respectively. In patients, they were (31.12±8.12) %, (41.75± 10.91) % and 0.84±0.22 before treatment, and (36.21±8.71) %, (35.08±10.14) % and 1.19±0.27 after treatment, respectively (P 〈 0.05 ). The patients were divided into treatment effective and non- effective groups by pain score. Before treatment, the immunologic parameters in the two groups had no significant differences(P 〉 0.05). After treatment, the frequencies of CD4^+ and CD8^+ subsets, CD4 ^+ to CD8^+ ratios and the number of metastatic loci in the effective group were (37.81 ± 5. 18) % , (33.17 ± 6.38) %, 1.33 ±0.31 and 6.64 ±3. 11, respectively, while in the treatment non-effective group, they were (32.09 ±5.72) % , (39.99 ±5.38) % , 0.82 ±0.22 and 9.87 ± 3.46, respectively (P 〈0.05). Conclusion The immune functions in patients with simple bone metastases are inhibited. Treatment with ^89SrCl2 may improve their immunity to certain extent. The degree of recovery in the treatment effective patients was better than that in the treatment non-effective cases.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2005年第12期731-733,共3页
Chinese Journal of Oncology
基金
黑龙江省十五攻关资助项目(GC02C147-01)