摘要
目的探讨血浆血管内皮生长因子(VEGF)、6-酮-前列腺素F1α(6-酮-PGF1α)、8-表氧-前列腺素F2α(8-表氧-PGF2α)和11-去氢-血栓烷B2(DH-TXB2)水平在糖尿病肾病(DN)中的变化及临床意义。方法对68例DN患者和20例正常对照进行血浆VEGF、6-酮-PGF1α、8-表氧-PGF2α和DH-TXB2等检测,分别分析其与尿白蛋白分泌率(UAER)的相关关系。结果DN各组血浆VEGF、8-表氧-PGF2α、DH-TXB2水平均显著高于对照组(P<0.001),且临床期DN组(CDN)高于早期DN组(EDN)(P<0.05),血浆6-酮-PGF1α水平显著低于对照组(P<0.05),且CDN组低于EDN组(P<0.05)。经相关分析,血浆VEGF(r=0.3694,P<0.05)、DH-TXB2(r=0.4391,P<0.05)和8-表氧-PGF2(r=0.4831,P<0.05)均与UAER呈正相关,而血浆6-酮-PGF1α与UAER呈负相关(r=-0.3892,P<0.05)。结论VEGF过度表达、血管内皮损伤、血小板活化和脂质过氧化是DN发生、发展的重要机制。
Objective To investigate the clinical significance of plasma vascular endothelial growth factor（VEGF）, 6-keto-prostaglandin la（6-keto-6-PGFla）, 8-epi-prostaglandin F2α （8-epi-PGF2α） and 11-dehydrothromboxane B2（DH-TXB2） in patients with diabetic nephropathy（DN）. Methods The plasma VEGF, 6-keto-PGFla, 8-epi-PGF2α and DH-TXB2 levels in 68 DN patients and 20 normal controls were assayed. The relatonship of these indices with the urine alblume excretion rate（UAER） was discussed. Results The results showed that the concentrations of plasma VEGF, 8-epiprostaglandin F2α and DH-TXB2 in DN patients were significantly increased than that in the normal controls. Those indices in CDN patients increased than that in EDN. Plasma 6-keto-PGFla level in patients with DN was lower than that in the normal controls. While it was lower in CDN than that in EDN. The levels of plasma VEGF, 8-epi-PGF2α and DH-TXB2 were positively correlated with UAER, while the concentrations of plasma 6-keto-PGFla were negatively correlated with UAER. Conclusion Overexpression of the VEGF, injury of endothelial cell,oxidative stress and platelet activation may be the one of the mechanism of the progress in DN.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第6期1020-1022,共3页
Suzhou University Journal of Medical Science
