摘要
目的探讨脑脊液中自由基在肾缺血再灌注(I/R)损伤后的变化规律。方法20只健康新西兰兔随机分为对照组和肾I/R组,检测和比较I/R后24h脑脊液中尿素氮(BUN)、肌酐(Cr)、超氧化物歧化酶(SOD)和丙二醛(MDA)的含量。结果与对照组相比,在肾I/R后24hIR组脑脊液中的BUN、Cr和MDA均升高(P<0.05),I/R组脑脊液SOD活性降低(P<0.05)。结论肾I/R损伤后,脑脊液和脑组织中代谢废物积聚同时自由基生成增多,提示肾I/R损伤后神经系统功能的改变可能与其相关。
Objective To determine the changing patterns of free radical in cerebrospinal fluid after renal ischemiareperfusion（I/R） injury. Methods Twenty rabbits were divided randomly into control group and renal I/R injury group（ I/R group）, the contents of BUN, Cr, SOD and MDA in cerebrospinal fluid were determined and compared respectively after 24 h from reperfusion in renal. Results Compared with control group,24 h after renal I/R, the contents of BUN, Cr and MDA increased（P〈0. 05） ,while the activity of SOD dropped（P〈 0.05）in cerebrospinal fluid of the IR group. Conclusion Renal I/R injury can lead to the accumulation of metabolism and the creation of free radical in cerebrospinal fluid and the tissues of brain , which indicates that the dysfunction of nerve system may be related to the change of free radical in cerebrospinal fluid after I/R injury in renal.
出处
《新乡医学院学报》
CAS
2006年第1期25-26,共2页
Journal of Xinxiang Medical University
关键词
肾缺血再灌注损伤
脑脊液
自由基
renal ischemia-reperfusion Injury
cerebrospinal fluid
free radical
