摘要
目的探讨不动杆菌致下呼吸道感染的临床特点、危险因素和对抗生素的敏感性。方法对36例不动杆菌致下呼吸道感染患者的临床、痰细菌培养及药敏结果进行回顾性分析。结果36例均为院内感染。>65岁者23例(63.9%);患有2种或2种以上基础疾病者20例(55.6%);36例发病前均应用多种抗生素;应用糖皮质激素或免疫抑制剂18例(50%),侵袭性治疗10例(27.8%)。雾化吸入13例(36.1%)。死亡9例,病死率25%。临床症状及X线表现无特异性。药敏试验呈现对多种常用抗革兰氏阴性杆菌的抗生素耐药。结论老年、基础疾病多、免疫力低下、长期应用抗生素、侵袭性治疗及雾化吸入为不动杆菌下呼吸道感染的危险因素。其临床症状重,耐药率高,预后差。亚胺培南、左旋氧氟沙星、头孢哌酮-舒巴坦、头孢他啶为较有效药物。
Objective To investigate the clinical features, risk factors and antibiotic sensitivity of 36 patients with lower respiratory tract infection（LRTI）induced by Acinetobacter. Methods Retrospective study on the clinical data, including clinical features, sputamentum bacterial culture and drug sensitivity 36 patients with LRTI induced by Acinetobacter were performed. Results All of 36 patients were hospital onset of infection, Twenty three patients （63.9 % ） were over 60 years old;Twenty patients （55.6%） suffered from two or more than two kinds of underlaying diseases;All 60 patients（ 100% ） were administered with various kinds of antibiotics, 18 （50%） with glucocorticoids or immune depressant, 10 patients（27. 8 % ） were performed with invasive managements, 13 patients（ 36.1% ） wre performed with atomization inhalation, 9 （25 % ） were dead. Clinical manifestations and chest x-ray appearance were no specificity. The drug sensitive tests demonstrated that these strains were multiresistant to antibiotics, which were Gram-Negative bacillus. Conclusion The risk factors of induced by Acinetobacter are old ages, more underlaying disease, hypoimmunity, long-term use of antibiotic, invasive managements and atomization inhalation. Its clinical symptoms are serious, higher drug resistant rate and prognosis are poor. Imipenem, Levofloxacin, Sulperazone and Ceftazidime are effective drugs for the treatment of LRTI induced by Acinetobacter.
出处
《新乡医学院学报》
CAS
2006年第1期80-81,共2页
Journal of Xinxiang Medical University
关键词
不动杆菌属
下呼吸道感染
抗生素
Acinetobacter
lower respiratory tract infection
antibiotics
