摘要
目的观察芩栀胶囊对比格(Beagle)犬有无长期毒性作用。方法芩栀胶囊以4.0,8.0,16.0 g/kg剂量(分别相当于临床成人日用剂量的10,20,40倍),连续给Beagle犬灌胃给药28 d,停药14 d,分别称量动物体重,计算脏器系数,测定血液学和血液生化学指标,并作心电图和病理组织学检查。结果芩栀胶囊各剂量组动物的一般状况、体重、摄食量、主要脏器系数、心电图、血液学指标及血液生化学指标,与正常对照组比较,均未见明显差异;病理检查未见与药物毒性相关的主要脏器组织形态学改变;停药后也未见药物延迟性毒性反应。结论芩栀胶囊长期用药无明显毒性,推测临床拟用剂量是安全的。
Objective To observe the Beagle dog chronic toxicity induced by Qinzhi Capsule taken orally. Methods The Beagle dogs were orally given Qinzhi Capsule for 28 days with the doses of 4.0,8.0 and 16.0g（ crude medicinal materials）/kg（ 10,20 and 40 times of clinic dose） and for 14 days of stopping administration. The Beagle dog＇ s weights, organ coefficients, the indexes of hematology and biochemistry were determined. The cardiogram and the pathological examination were carried out. Results The outer appearance and behavior, weights, organ coefficient, the cardiogram, the indexes of hematology and biochemistry in Beagle dogs had no significant difference by comparing with control group. The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration. Conclusion Qinzhi Capsule has no significant toxicity for long - term administration on Beagle dogs. It infers that the drawing up doses in clinic will be safe.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第1期58-61,共4页
Lishizhen Medicine and Materia Medica Research
关键词
芩栀胶囊
长期毒性
比格犬
Qinzhi Capsule
Chronic Toxlcity
Beagle Dog
