摘要
目的:研究六味地黄丸对自发性2型糖尿病鼠(otsukalong-evanstokushimafattyrats,OLETF鼠)胰腺形态学改变的影响。方法:OLETF鼠40只,随机分为六味地黄丸干预组和对照组,LETO(long-evanstokushimaotsuka)鼠10只作为正常对照组。干预组从8周龄起以六味地黄丸2.4g/(kg·d)灌胃给药,其余两组以等量蒸馏水灌胃。每周监测体重,定期OGTT试验检测血糖,胰腺切片HE染色观察组织学改变。结果:OLETF鼠体重和血糖显著高于LETO鼠。随病程进展,OLETF鼠对照组胰岛早期表现为肥大增生,晚期破坏、纤维化程度明显高于LETO鼠。干预组胰岛结构保存明显好于对照组,且干预组负荷后血糖显著低于对照组。结论:六味地黄丸能有效地保护OLETF鼠胰腺的组织形态结构并改善其糖代谢能力。
Objective To investigate the effects of Liuwei Dihuang Pills on morphological change of pancreas in OLETF rats. Methods 40 male OLETF rats were divided randomly into Liuwei Dihuang Pills group（Group LW） and control group（Group CN） （ n = 20 per group）. 10 male LETO rats were used as normal control group（Group LETO）. Rats of Group LW were given Liuwei Dihuang Pills[2.4 g/（kg·d） ] intragastrically since age 8 weeks. The body weight is recorded per week and blood glucose is determined by OGTT. The paraffin section of pancreas was stained with hematoxylin and eosin to observe the morphdogical changes. Results The body weight and blood glucose of OLETF rats is significantly higher than that of LETO rats. The disorgnization of pancrease isht in Group CN is severer than Group LW with the development of diabetes and the postprandial blood glucose of Group CN is higher than Gruoup LW. Conclusion Liuwei Dihuang Pills can protect the structure of pancreas and the ability of glycometabdism effectively.
出处
《实用医学杂志》
CAS
2006年第2期125-127,共3页
The Journal of Practical Medicine
基金
国家自然科学基金资助项目(30371839)
广东省重点科技攻关项目(社会发展攻关2003C34424)
广东省科技计划项目(2004B30701011)
关键词
糖尿病
2型六味地黄汤
大鼠
近交OLETF
Diabetes mellitus, type 2 Liuwei dihuang decoction Rats, inbredoletf OLETF
