摘要
本文就硝苯吡啶(Nif)对慢性肺心病肾脏血流动力学的影响进行了研究。18例肺心病合并呼吸衰竭的患者随机分为两组,治疗组在常规疗法的基础上,口服Nif 10mg,每日3次。对照组保持常规疗法,我们发现Nif治疗组一周后平均动脉压(MBP)下降,系统血管阻力(SVR)下降,每分钟心输出量(CO)增加;肾血流量(RBF)增加,肾小球滤率(GFR)增加,肾血管阻力(RVR)下降,但滤过分数(FF)、RBF/CO及RVR/SVR未见明显改变。我们认为Nif用于治疗慢性肺心病,改善心、肺血流动力学的同时能改善肾脏血流动力学及肾功能。因此,硝苯吡啶可作为治疗慢性肺心病合并心力衰竭和肾功能衰竭的一种有效药物。
The central and renal hemodynamic effects of nifedipine were evaluated in patients with severe chronic cor prlmonale. Eighteen paticnts (nine men, nine women ) with a mean age of 58+9 years were divided into two groups. One group was treated with nifedipine in the base of general treatment. The other was given only general treatment as controls. The data obtained suggested that the central and renal hemodynamics and renal function were improved after a week of nifedipine therapy. Oral nifcdipine ( 10mg, three times a day) decreased systemic vascilar resistance ( SVR ), mean arterial blood pressular (MBP) and renal vaselar rcsisiancc (RVR) , and increased cardiac output (CO), rcrai blood flow ( RBF) and glomcruler filtration raie(GFR)No sigai-ficent change was cbserved in the raio of SVR/RVR, RBF/CO and GFR/RBF. We believe that the improvement of remal hemodynamics and the function is associated with the improvement of cennal hemodynamics Thus, nifedipine may be served as an effectiye remedy for preventing or forestalling renal and heart insufficiency complicated by chronic pulmonary heart disease.
出处
《蚌埠医学院学报》
CAS
1989年第2期91-95,共5页
Journal of Bengbu Medical College
关键词
硝苯吡啶
肺心病
血流动力学
肾
nifedipine
chronic cor pulmonale
renal hcmodynnmic
