摘要
本文以酶联免疫吸附法(ELISA)测定了54例不同类型及不同并发症的冠心病患者与30名健康人的血浆Lp(a)浓度。心肌梗塞组和心绞痛组的Lp(a)浓度均高于对照组,并发糖尿病组Lp(a)浓度显著高于其他各组,无并发症且年龄较轻者Lp(a)浓度显著高于年龄较高者。表明血浆高Lp(a)水平是冠心病的遗传危险因素,但其升高的程度不能反映冠心病的临床类型或严重程度;并发糖尿病是老年冠心病患者血浆Lp(a)浓度升高的原因之一。
Plasma Lp (a) Ievels were determmed by cnzymclinked immunodorbe.nl assay m 54 pa-tients with different types and complications of CHD and m 30 healthy people. Plasma 1-p (a) concentra-tions in both the myocardial infarction group and the angina pectoris group were sigmficantly higher than m control group. Lp (a) concentrations m CIID with diabefes mellitus group were significantly higher fhan mthe other groups. Lp (a) concentrations with CHD without complication (age;-a,45 yaer - old subgroup) were sigmficantly higher than m the other groups. It suggests that Lp (a) is a genitic nsk factor for CHD and the extenf of increase in Lp (a) concentration can not reflect the rlmical types and the seventy of CHD. Diabetes mellitus complication may be one of the cause for the increase of Lp (a) concentration in elder patients with CHD.
关键词
脂蛋白(a)
ELISA
冠心病
Lipoprotein (a) Enzyme- linked immunosorbent assay
Coronary heart disease
