摘要
制备了pH敏感性壳聚糖/聚乙烯醇(CS-PVA)水凝胶,研究了该水凝胶在室温下不同pH值介质中的溶胀比。发现在酸性溶液中,凝胶的溶胀比远大于在碱性溶液中的溶胀比,且其在不同pH值溶液中具有可逆溶胀-收缩行为,对药物氟哌酸具有缓释效果。
pH sensitive ehitosan-polyvinyl alcohol hydrogels were prepared. The swelling ratio of hydrogels in different pH medium was investigated. The results showed that the ratio of hydrogels in acid medium were higher than the ratio of hydrogels in base medium. Furthermore, The hydrogels had good swelling-contracting reversibility in the solution which pH value was alternately changed, and can be used as the drug-release support of norfloxacin.
出处
《化工新型材料》
CAS
CSCD
北大核心
2005年第12期51-53,共3页
New Chemical Materials
基金
国家自然基金(20274034)
西北师范大学青年教师基金(NWNU-QN-04-27)
关键词
PH敏感性
壳聚糖
聚乙烯醇
半互穿聚合物网络
药物释放
pH-sensitivity, chitosan, polyvinyl alcohol, semi-interpenetrating network（Semi-IPN）, drug release
