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SYNERGY OF WALL SHEAR STRESS AND CIRCUMFERENTIAL STRESS IN STRAIGHT ARTERIES 被引量:15

SYNERGY OF WALL SHEAR STRESS AND CIRCUMFERENTIAL STRESS IN STRAIGHT ARTERIES
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摘要 The Wall Shear Stress (WSS) generated by blood flow and Circumferential Stress (CS) driven by blood pressure have been thought to play an important role in blood flow-dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis. The WSS and CS in straight arteries were calculated by measuring the blood pressure, center-line velocity, wall thickness, and radius of vessels. The WSS and CS in the time domain were then decomposed into the amplitude and phase in the frequency domain. The CS amplitude to the WSS amplitude ratio (referred as stress ampli tude ratio, Zs ) and the phase difference between the CS and the WSS (referred as stress phase difference, SPA) in the fre quency domain were calculated to characterize the synergy of the CS and WSS. Numerical results demonstrated that the CS is not in phase with the WSS, a time delay in the time domain or a stress phase difference in the frequency domain between the WSS and the CS exists. Theoretical analysis demonstrated that the Zs and SPA are primarily determined by the local fac tors (blood viscosity, local inertial effects, local geometry, loeal elasticity) and the input impedance of whole downstream arterial beds. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and stress phase difference SPA would be thought to be the appropriate indices to reflect the effects of states of whole downstream arterial beds on the local blood flow dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis. The Wall Shear Stress (WSS) generated by blood flow and Circumferential Stress (CS) driven by blood pressure have been thought to play an important role in blood flow-dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis. The WSS and CS in straight arteries were calculated by measuring the blood pressure, center-line velocity, wall thickness, and radius of vessels. The WSS and CS in the time domain were then decomposed into the amplitude and phase in the frequency domain. The CS amplitude to the WSS amplitude ratio (referred as stress ampli tude ratio, Zs ) and the phase difference between the CS and the WSS (referred as stress phase difference, SPA) in the fre quency domain were calculated to characterize the synergy of the CS and WSS. Numerical results demonstrated that the CS is not in phase with the WSS, a time delay in the time domain or a stress phase difference in the frequency domain between the WSS and the CS exists. Theoretical analysis demonstrated that the Zs and SPA are primarily determined by the local fac tors (blood viscosity, local inertial effects, local geometry, loeal elasticity) and the input impedance of whole downstream arterial beds. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and stress phase difference SPA would be thought to be the appropriate indices to reflect the effects of states of whole downstream arterial beds on the local blood flow dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis.
出处 《Journal of Hydrodynamics》 SCIE EI CSCD 2005年第6期752-757,共6页 水动力学研究与进展B辑(英文版)
基金 ProjectsupportedbytheNationalNaturalScienceFoundationofChina(GrantNos:10132020,10472027).
关键词 Wall Shear Stress (WSS) Circumferential Stress (CS) wall shear stress-circumferential stress synergy angiogenesis vascular remodeling atherosgenesis Wall Shear Stress (WSS), Circumferential Stress (CS), wall shear stress-circumferential stress synergy,angiogenesis, vascular remodeling, atherosgenesis
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参考文献8

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