摘要
为探讨补肾中药东方神丹对脑老化有无改善作用，观察了该药对老年大鼠某些脑区脂褐质的含量以及超氧化物歧化酶（ＳＯＤ）活性的影响及该药体外清除自由基的作用。结果表明：老年鼠海马锥体细胞的脂褐质蓄积明显多于年青鼠（Ｐ＜００１），如以５００个细胞计算，脂褐质占细胞质面积＞１／２的细胞占３６４％，而年青组未见此类细胞。喂服东方神丹后可明显减少老年大鼠下丘脑和海马脑区的脂褐质沉积（Ｐ＜００１），明显提高下丘脑ＳＯＤ活性（Ｐ＜００１），同时药物本身也有较强的清除自由基作用。
Experiments were performed in aged and young rats.Lipofuscin level and the activity of superoxide dismutase(SOD) in hippocampus and hypothalamus were observed.The effect of Dongfang Shendan (DFSD,a traditional Chinese medicine for invigorating kidney function) on the parameters mentioned above were also observed.The results suggested that compared with young rats,the accumulation of lipofuscin in hippocampus of aged rats increased notably,while the activity of SOD decreased significantly in hypothalamus.However,DFSD conld lower the lipofuscin level of hippocampus and hypothalamus,and increase the activity of SOD in hypothalamus of aged rats.In vitro test,using ESR method the scavenging rate of DFSD on free radicals increased dose dependently.The results indicated that DFSD played an important role in delaying the aging of brain by invigorating kidney function.
出处
《中日友好医院学报》
1996年第2期99-102,共4页
Journal of China-Japan Friendship Hospital
基金
国家八五攻关资助
