摘要
初步探讨慢性盆腔炎性不孕患者中医证型与免疫内分泌的关系。【方法】将75例患者辨证分为气滞血瘀、湿热瘀阻、肾虚血瘀和痰瘀互结4型,观察不同证型患者的IgG、IgA、IgM、IgE等体液免疫指标和雌二醇(E2)、孕激素(P) 等内分泌指标的变化情况,并与20例正常对照组比较。【结果】各证型的慢性盆腔炎性不孕患者的各项免疫指标以及血清 E2水平与正常组比较,差异均无显著性意义(P>0．05),而血清孕激素(P)水平比正常组下降(P<0．05),其中湿热瘀阻型组的血清孕激素水平比其他3种证型下降得更低(均P<0．05),而痰瘀互结型组则比其他3种证型稍高(均P< 0．05),气滞血瘀型和肾虚血瘀型之间差异无显著性(P>0．05)。【结论】慢性盆腔炎性不孕患者的血清孕激素水平比正常人降低,而不同证型患者的血清孕激素水平也存在一定的规律性。
[ Objective] To explore the relationship between TCM syndrome pattem and immuno-endocrine function in patients with infertility induced by chronic pelvic inflammation （CPI）. [ Methods ] Seventy-five patients with CPI- induced infertility were differentiated as four syndrome patterns： Qi stagnation and blood stasis （pattern 1）, damp-heat and blood stasis stagnation （pattern 2）, kidney deficiency with blood stasis （pattern 3） and phlegm blended with blood stasis （pattern 4）. The changes of humoral immunity parameters of IgG, IgA, IgM and IgE in the patients, as well as the endocrine parameters of estradiol （E2 ） and progesterone （P）, were observed and compared with 20 healthy volunteers. [ Results ] The differences of immune parameters and serum E2 were insignificant between the patients and the healthy （ P 〉 0.05）. Serum P level was much decreased in pattern 2 patients as compared with those in other pattern patients （ P 〈 0.05）, and a little higher in pattern 4 than those in other patterns （ P 〈 0.05）. The difference of serum F was insignificant between pattern 1 and pattern 3 （ P 〉 0.05）. [ Conclusion ] Serum P level is lower in the patients with CPI-induced infertility than that in the healthy, and varies in the patients with different patterns.
出处
《广州中医药大学学报》
CAS
2006年第1期29-31,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
