摘要
目的研究震颤停汤对帕金森病(PD)模型小鼠行为学的影响,初步探讨其治疗PD的机理。方法采用C57BL/6J褐鼠MPTP腹腔注射(ip)复制PD模型,观察震颤停汤对其行为学的影响,并探讨其作用机理。以上实验均与安坦组作对照。结果震颤停汤高剂量(10g生药/kg)、中剂量(5g生药/kg)、低剂量(2.5g生药/kg)能够显著缩短小鼠爬杆时间差值(P<0.01);高剂量能够显著增加小鼠自主活动(P<0.01)并能够增加小鼠悬挂能力评分(P<0.01)。结论震颤停汤能够增加小鼠的自主活动,提高肢体运动协调能力。震颤停汤对PD模型小鼠具有保护作用。
Objective To study the influence of quiver- killer soup to behaviorism of model rats suffered PD and to approach the mechanism of treating PD preliminarily. Methods C57BL/6J to give the rats MPTP intraperitoneal injection（ IP） to copy PDmodel, to observe the influence of quiver- killer soup to behaviorismt and to approach the mechanism. The above experiment should be compared with the artane group. Results The quiver - killer soup with the dosage large（ unprocessed drug 10g/kg） moderate（5k/kg） and small（2.5k/kg） can notably shorten the time difference of rats to climb pole（ P 〈 0.01）. Large dosage can notably improve the initiative activities（ P 〈 0.01} and the hanging ability（ P 〈 0.01 ）of the rats.Condution Quiver- killer soup can improve the initiative activities and the limbs coordination of the PD model rats and protect them.
出处
《陕西中医学院学报》
2006年第1期44-47,共4页
Journal of Shaanxi College of Traditional Chinese Medicine
基金
四川省科技厅攻关项目(03SG011-021)
关键词
震颤停汤
帕金森病
行为学
quiver - killer soup
Parkinson＇ s disease
behaviorism
