摘要
目的:制备白芷香豆素不同载体固体分散体,并检测其体外溶出特性。方法:选择聚乙二醇6000(PEG)、聚乙烯吡咯烷酮K30(PVP)、泊洛沙姆188等3种载体,用熔融法和溶剂法制备了白芷香豆素固体分散体,对其进行差示扫描量热分析以鉴别药物在载体中的存在状态,并以欧前胡素为检测指标,用高效液相色谱法,色谱柱:ThermoC18(150mm×4.6mm,5μm);流动相:甲醇-水(70∶30);流速:1.0mL/min;检测波长:302nm,进行了溶解度、体外溶出度测定。结果:熔融法和溶剂法可用于白芷香豆素固体分散体的制备,白芷香豆素类组分可充分分散在载体中并形成低共熔物,三种载体对白芷香豆素均有较好的增溶作用。结论:以聚乙烯吡咯烷酮K30制备的固体分散体使白芷香豆素的体外溶解度和溶出速率明显提高。
AIM ： To prepare the solid dispersions of angelica dahurica coumarins and measure their dissolution characteristics. METHODS： The solid dispersions were obtained by using the melted and dissolved methods with PEG6000, PVP and poloxamer188 as carriers respectively. The existing state of the coumarins in the solid dispersions were identificated by the differential scanning calorimetery. The dissolution characteristics of the solid dispersions in vitro were analyzed by HPLC method under the chromatographic conditions with ThermoCLa （150 mm ×4.6 mm,5 μm） as analytial column and methanol/water （70： 30）as mobile phase, using imperatorin as testing index. RESULTS： The melted and dissolved methods can be used to prepare the solid dispersions. The coumarins were completely dispersed in carrier and formed an euctics mixture with the carrier. The dissolution rates of all solid dispersion were increased obviously. CONCLUSION： The solid dispersion prepared with PVP can increase the solubility and dissolution of the coumafins.
出处
《中成药》
CAS
CSCD
北大核心
2006年第1期20-23,共4页
Chinese Traditional Patent Medicine
关键词
白芷香豆素
固体分散体
溶解度
热分析
体外溶出度
angelica dahurica coumarins
solid dispersion
solution
calorimetery analysis
dissolution in vitro
