摘要
目的：观察整蛋白型肠内营养对急性胰腺炎病人血谷氨酰胺水平的影响。方法：10例急性胰腺炎病人胃肠功能恢复后，通过鼻肠管给予全量肠内营养支持3天后，禁食6h，于8：00开始给予能全力，分别于用前、用后0．5、1．0、1．5、2．0、2．5、3．0、3．5、4．0、5．0和6．0h，留取血标本。次日8：00停用能全力，于停用前、停用后0．5、1．0、1．5、2．0、2．5、3．0、3．5、4．0、5．0和6．0h留取血标本，用高效液相色谱法检测血谷氨酰胺浓度。结果：所有病人给予能全力后6h，血谷氨酰胺维持在400～600μmol／L水平。6例血谷氨酰胺浓度上升很快，按恒定速度给予能全力后，维持在稳定水平。4例经过一段持续偏低期后逐渐上升到400～600μmol／L水平。所有病人在停用能全力后血谷氨酰胺浓度明显下降。其中6例下降很快，4例在短暂上升后逐渐下降。结论：不同急性胰腺炎病人由于肠功能差异，给予整蛋白型肠内营养后血谷氨酰胺浓度提高有快慢不同和高低之分，但能够维持血谷氨酰胺浓度在正常生理浓度范围，停用后明显下降。
Objective ： To investigate the effect of enteral nutrition on the plasma glutamine concentration in acute pancreatitis patients. Methods： All patients were placed by nasojejunal tubes after the intestinal function was restored. The blood samples were drawn at 0,0.5,1.0,1.5,2.0,2.5,3.0,3.5,4.0, 5.0 and 6.0 h after beginning enteral nutrition. On the second day, the blood was sampled at 0,0.5, 1.0,1.5,2.0,2.5,3.0,3.5,4.0,5.0 and 6. Oh after stopping enteral nutrition. The glutamine concentration was assayed by HPLC. Results： The plasma glutamine concentration of all patients immediately dropped after stopping enteral nutrition. The plasma glutamine concentration was maintained from 400 to 600 p, mol/L after the patients were given enteral nutrition. Six patients obviously increased after enteral nutrition, while four patients gradually improved after a period of low level. Conclusion： The plasma glutamine concentration was maintained at the normal level in acute pancreatitis patients after enteral nutrition was given. However, the increase of glutamine level was different at the rate and degree because the intestinal function of patients was not the same.
出处
《肠外与肠内营养》
CAS
2006年第1期8-10,共3页
Parenteral & Enteral Nutrition
基金
国家自然科学基金资助(批准号:30500404)
关键词
肠内营养
急性胰腺炎
谷氨酰胺
Enteral nutrition
Acute pancreatitis
Glutamine
