摘要
巨噬细胞是结核分支杆菌在体内的主要宿主细胞,发生凋亡后,可杀灭胞内感染的结核分支杆菌其在体内的扩散。不同毒力的结核分支杆菌的感染可诱导巨噬细胞产生不同水平的凋亡。与结核分支杆菌减毒株及无毒株相比,结核分支杆菌毒力株可通过一系列机制抑制巨噬细胞凋亡,以逃避巨噬细胞的杀伤。进一步了解结核分支杆菌感染与巨噬细胞凋亡之间的机制与相关分子基础,有助于人们更好地预防和控制结核病。
出处
《国际检验医学杂志》
CAS
2006年第1期65-68,70,共5页
International Journal of Laboratory Medicine
参考文献16
-
1Danelishvili L,McGarvey J,Li YJ,et al.Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.Cell Microbiol,2003,5(9):649-660.
-
2Balcewicz-Sablinska MK,Keane J,Kornfeld H,et al.Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF R2,resulting in inactivation of TNF-alpha.J Immunol,1998,161(5):2636-2641.
-
3Riendeau CJ,Kornfeld H.THP-1 cell apoptosis in response to Mycobacterial infection.Infect Immun,2003,71(1):254-259.
-
4Keane J,Remold HG,Kornfeld H.Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages.J Immunol,2000,164(4):2016-2020.
-
5Ciaramella A,Cavone A,Santucci MB,et al.Induction of apoptosis and release of interleukin-1 beta by cell wall-associated 19-kDa lipoprotein during the course of mycobacterialinfection.J Infect Dis,2004,190(6):1167-1176.
-
6Dao DN,Kremer L,Guerardel Y,et al.Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.Infect Immun,2004,72(4):2067-2074.
-
7Briken V,Porcelli SA,Besra GS,et al.Mycobacterial lipoarabinomannan and related lipoglycans:from biogenesis to modulation of the immune response.Mol Microbiol,2004,53(2):391-403.
-
8Nuzzo I,Galdiero M,Bentivoglio C,et al.Apoptosis modulation by mycolic acid,tuberculostearic acid and trehalose 6,6'-dimyco late.J Infect,2002,44(4):229-235.
-
9Spira A,Carroll JD,Liu G,et al.Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis:a pivotal role for tumor necrosis factor.Am J Respir Cell Mol Biol,2003,29(3):545 551.
-
10Mogga SJ,Mustafa T Sviland L,et al.Increased Bcl-2 and re duced Bax expression in infected macrophages in slowly progressive primary murine Mycobacterium tuberculosis infection.Scand J Immunol,2002,56(4):383-391.
同被引文献26
-
1D.van Soolingen,K.Kremer,H-J.Duanmu,王民,张立兴.2000年中国结核病流行病学抽样调查菌株分子流行病学特征[J].国际结核病与肺部疾病杂志,2006,1(2):47-51. 被引量：4
-
2Bermudez LE,Danelishvili L,Early J,et al.Mycobacteria and macrophage apoptosis:complex struggle for survival[J].Microbe,2006,1(8):372-375.
-
3Dubnau E,Fontan P,Manganelli R,et al.Mycobacterium tuberculosis genes induced during infection of human macrophages[J].Infect Immun,2002,70 (6):2787-2795.
-
4Danelishvili L,Mc Garvey J,Li YJ,et al.Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells[J].Cell Microbiol,2003,5(9):649-660.
-
5Rios-Barrera VA,Campos-Pena V,Aguilar-Leon D,et al.Macrophage and T lymphocyte apoptosis during experimental pulmonary tuberculosis:their relationship to mycobacterial virulence[J].Eur J Immunol,2006,36(2):345-353.
-
6Joardar SN,Ram GC,Goswami T.Dynamic changes in cellular immune responses in experimental bovine tuberculosis[J].Med Sci Monit,2002,8(11):BR471-BR480.
-
7Riendeau C J,Kornfeld H.THP-1 cell apoptosis in response to mycobacterial infection[J].Infect Immun,2003,71 (1):254-259.
-
8Keane J,Remold HG,Kornfeld H.Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages[J].J Immunol,2000,164(4):2016-2020.
-
9Fratazzi C,Arbeit RD,Carini C.et al.Macrophage apoptosis in mycobacterial infections[J].J Leukoc Biol,1999,66(5):763-764.
-
10Fontan P,Aris V,Ghanny S.et al.Global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection[J].Infect Immun,2008,76 (2):717-725.
引证文献2
-
1郭文秀,吴胜男,王小芸,张敏.基于网络药理学的百部联合川贝母治疗肺结核的作用机制研究[J].中华临床医师杂志（电子版）,2023,17(3):335-342.
-
2刘毅,孙照刚,任卫聪,田苗,李妍,李传友.结核分枝杆菌对人急性白血病单核细胞株THP-1凋亡和死亡水平的影响[J].中国医学科学院学报,2009,31(4):417-422.
-
1吴朝阳.从脓液中同时分离出金黄色葡萄球菌和结核分支杆菌[J].检验医学与临床,2009,6(3):223-223.
-
2分子免疫学[J].国外科技资料目录（医药卫生）,2002(10):19-22.
-
3代雪玲,务孔兴,鲁玲,吴宇明.结核分支杆菌特异蛋白抗原研究进展[J].兵团医学,2010(1):40-43.
-
4徐永忠,白海涛,胡忠义,陈建平,淳于俐娟,韦毅,王洪海.结核分支杆菌诱导宿主细胞肌动蛋白重排和表达改变[J].中华结核和呼吸杂志,2003,26(1):30-33.
-
5结核病[J].国外科技资料目录（医药卫生）,2001(12):28-29.
-
6王琪,王磊,张威.白细胞介素12对结核分支杆菌感染小鼠的影响[J].齐齐哈尔医学院学报,2003,24(4):361-362. 被引量：2
-
7洪葆.结核性腹膜炎43例误诊分析[J].临床医学,2009,29(10):120-120. 被引量：1
-
8霍云奎,张安庆,李伟,董正.胸壁结核50例外科治疗疗效分析[J].山西医药杂志（上半月）,2009,38(11):1050-1051. 被引量：1
-
9王秀勤,葛成群,赵彤,赵善良.住院肺结核病人693例临床特征分析[J].齐鲁医学杂志,2013,28(1):73-75. 被引量：7
-
10余连锋,朱杰,许坚,施南峰,沈晓瑜.重组人白细胞介素-2辅助治疗复治肺结核疗效观察[J].现代实用医学,2008,20(7):542-543. 被引量：2
