摘要
目的观察长期过量碘摄入对大鼠血清TC和TG水平的影响,并对其在评价过量碘危害中的意义进行探讨。方法将60只Wistar大鼠按体重随机分为6组:A组正常对照组,给予去离子水;B～F组为过量碘组,碘剂量分别为1800、3600、7200、14000和28000μgL,喂饲以KIO3配制成不同浓度的高碘水。3个月后,观察甲状腺病理变化,测定尿碘水平、血清甲状腺激素水平和血脂水平。结果各过量碘组大鼠甲状腺未出现明显病理组织学改变。各过量碘组大鼠的尿碘水平随着碘剂量的升高显著升高。TT4水平呈剂量依赖性的降低,在7200μgL组开始与对照组相比有显著性差异。TT3水平各组间无显著性差异。血清TC水平与碘剂量呈显著正相关,在3600μgL组就显著高于正常对照组。TG水平虽有升高,但各组间无显著性差异。血脂与甲状腺激素和尿碘水平的相关性分析表明,血清TC水平与尿碘水平呈显著正相关,与TT4水平呈显著负相关。结论长期过量碘摄入会升高大鼠血脂水平,血脂可以与尿碘、血甲状腺激素一起作为监测过量碘摄入的生物标志物。
Objective To study effect of excessive iodine exposure on the serum TC and TG level in rats. Methods According to body weight, 60 Wistar rats were divided into 6 groups and given drinking water including different doses of iodine. The iodine concentrations were 0（control）, 1800, 3600, 7200, 14000 and 28000μg/L, respectively. Three months later, related indices were determined. Results In excessive iodine groups, no obvious changes of thyroid morphology was observed. Urinary iodine level increased dose-dependently. Excessive iodine intake resulted in a significant reduce of serum TT4 level and an obvious inerease of serum TC level in a dose-dependent manner. The positive correlation was observed between serum TC and urinary iodine. There was the negative correlation between serum TC and serum TT4 .Conclusion Excessive-iodine exposure resulted in an increase in serum TC level. And serum lipids, together with urinary iodine and serum thyroid hormones, could be used as biomarkers for excessive iodine exposure.
出处
《卫生研究》
CAS
CSCD
北大核心
2006年第1期108-110,共3页
Journal of Hygiene Research
基金
国家自然科学基金重点项目(No.30230330)
关键词
过量碘
血脂
甲状腺激素
尿碘
生物标志物
excessive iodine, serum lipids, thyroid hormones, urinary iodine, biomarker
