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PI3K/Akt信号通路异常与白血病 被引量：4

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摘要 PI3K/Akt途径作为细胞内重要信号转导通路之一,通过影响下游凋亡相关蛋白、细胞周期调节蛋白等效应分子的活化过程,在细胞内发挥着抑制凋亡、促进增殖的关键作用。PI3K/Akt通路分子的基因突变,或上游调控信号的异常放大,均可导致该通路过度激活,细胞生存与凋亡失衡,正常细胞发生恶性转化。近年来的研究发现,PI3K/Akt通路的持续性活化在白血病发病中起着重要作用,针对这一异常设计的靶向药物也已陆续在白血病治疗中得到应用。本文综述了PI3K/Akt通路异常与白血病关系的研究进展。
作者 王东海 王建祥
机构地区 中国医学科学院中国协和医科大学血液学研究所血液病医院
出处 《国际输血及血液学杂志》 CAS 2006年第1期21-24,共4页 International Journal of Blood Transfusion and Hematology
关键词 白血病 PI3K 凋亡 靶向治疗
分类号 R733.7 [医药卫生—肿瘤]
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参考文献24

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同被引文献41

  • 1许德顺,张蕴莉,王莹,许讴.α_5、β_1整合素亚基在肺腺癌细胞凋亡中作用的实验研究[J].锦州医学院学报,2003,24(6):1-3. 被引量：3
  • 2苗丽君,王静.Akt与肿瘤的研究进展[J].国外医学（生理病理科学与临床分册）,2004,24(5):406-409. 被引量：38
  • 3Katarzyna Guzinska-Ustymowicz,Andrzej Kemona.Transforming growth factor beta can be a parameter of aggressiveness of pT1 colorectal cancer[J].World Journal of Gastroenterology,2005,11(8):1193-1195. 被引量：25
  • 4王恒邦,许建华,温彩霞,黄秀旺,陈元仲.雷公藤内酯醇体内外抗肿瘤作用[J].福建医科大学学报,2007,41(4):304-307. 被引量：26
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国际输血及血液学杂志
2006年 第1期

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