摘要
以Ag／AgCl丝为基体依次外涂含0．1mol／L KCl的琼脂凝胶膜及含四苯硼-司帕沙星缔合物的PVC膜，制备了一种双涂膜司帕沙星选择电极。采用正交设计法，研究了离子缔舍物的种类、活性物在膜中的浓度及增塑剂三因素对电极的影响。电极的线性范围为1．0×10^-5～1．0×10^-3mol／L，检出限为2．4×10^-6mol／L，斜率为28．8mV／decade（16℃），可直接用于司帕沙星片剂的含量测定，回收率为99．6％～101．1％，结果与文献法一致。
A doubly coated sparfloxacin membrane selective electrode was prepared. An Ag/AgCl wire was eoated by a layer of agar gel membrane containing 0.1 mol/L KCl and a layer of PVC membrane containing sparfloxacin-tetraphenylboron ion-pair eomplex on its suffaee successively. The influences of various ion-pair complexes, concentrations of activators in membrane phase and plastieizers on the properties of electrode were studied by orthogonal design. The linear response range of the electrode is 1.0×10^-5～1.0×10^-3mol/L. The deteetion limit is 2.4 ×10^-6 mol/L. The Nernst slope is 28.8 mV/deeade（16℃）. The electrode can be used for potentiometrle determination of sparfloxaein tablets direetly. The recovery is 99.6% - 101 . 1% . The results agree with UV method.
出处
《分析试验室》
CAS
CSCD
北大核心
2006年第1期95-98,共4页
Chinese Journal of Analysis Laboratory
基金
河北省科技厅攻关项目(99276422D)
关键词
司帕沙星
双涂膜
离子选择电极
Sparfloxacin
Doubly coated membrane
Ion-selective electrode
