期刊文献+

2型糖尿病合并大血管病变患者肝细胞生长因子水平观察 被引量:5

原文传递
导出
摘要 目的观察2型糖尿病合并大血管病变患者肝细胞生长因子(HGF)水平的变化,探讨HGF与2型糖尿病大血管病变发生的关系。方法用酶联免疫吸附法测定2型糖尿病患者、无糖尿病的大血管病变患者以及正常对照组的血清HGF水平。结果与正常对照组相比,2型糖尿病伴或不伴大血管病变患者及无糖尿病的大血管病变患者血清HGF水平明显增高(P<0.05或P<0.01);无糖尿病大血管病变患者和2型糖尿病无大血管病变患者血清HGF水平差异无显著性;2型糖尿病伴大血管病变患者血清HGF水平较2型糖尿病无大血管病变患者及无糠尿病大血管病变者明显增高(P<0.05)。结论2型糖尿病患者血清HGF水平显著增高,2型糖尿病合并大血管病变者增高更明显;HGF可作为反映糖尿病患者大血管病变严重程度的指标之一。
出处 《中国综合临床》 北大核心 2006年第2期140-142,共3页 Clinical Medicine of China
  • 相关文献

参考文献9

  • 1Morishita R,Nakmura S,Hayashi S,et al.Contribution of a vascular modulator,hepatocyte growth factor (HGF),to the pathogenesis of cardiovascular disease[J].J Atheroscler Thromb,1998,5 (4):128-134.
  • 2Morishita R,Nakamura S,Nakamura Y,et al.Potential role of endothelium-specific growth factor,hepatocyte growth factor,an endothelial damage in diabetes mellitus[J].Diabetes,1997,46 (7):138-148.
  • 3Nakamura S,Morishita R,Moriguchi A,et al.Hepatocyte growth factor as a potential index of complication in diabetes mellitus[J].J Hypertens,1998,16(9):2 019-2 026.
  • 4Haug C,Schmid-Kotsas A,Zorn U,et al.Hepatocyte growth factor is unregulated by low-density lipoproteins and inhibits endothelin-1 release[J].Am J Physiol,2000,279(12):2 865-2 871.
  • 5Nishimura M,Ushiyma M,Ohtsuka K,et al.Serum hepatocyte growth factor as a possible indicator of vascular lesions[J].J Clin Endocrinol Metab,1999,84(11):2 475-2 480.
  • 6Nakamura M,Moriguchi A,Morishita R,et al.A novel vascular modulator,hepatocyte growth factor (HGF),as a potential index of the severity of hypertension[J].Biochem Biophys Res Commun,1998,242 (5):238-249.
  • 7Nakamura Y,Morishita R,Nakamura S,et al.A vascular modulator,hepatocyte growth factor is associated with systolic pressure[J].Hypertension,1996,28 (6):409 -413.
  • 8Morishita R,Moriguchi A,Higaki J,et al.Hepatocyte growth factor (HGF) as a potential index of severity of hypertension[J].Hypertens Res,1999,22 (5):161-167.
  • 9Kawamoto R,Oka Y,Yoshida O,et al.Significance of serum circulating hepatocyte growth factor in the development of carotid atherosclerosis[J].J Atheroscler Thromb,2003,10 (3):154 -159.

同被引文献24

引证文献5

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部