摘要
目的 了解医源性腹泻患者肠道菌群失调原因菌的耐药性，为临床治疗不同原因菌引起的Ⅲ度肠道菌群失调及内源性感染提供选药依据。方法用VITEK-ATB系统对该院2001～2003年间医源性腹泻患者肠道菌群失调原因菌及其耐药性进行统计分析。结果引起肠道菌群失调的原因菌按组成比大小依次是肠球菌（31．90％）、酵母样真菌（27．24％）、变形菌属（16．34％）、铜绿假单胞菌（6．23％）、柠檬酸杆菌属（5．84％）、克雷伯菌（5．45％）、产毒素A的难辨梭菌（5．06％）、金黄色葡萄球菌（1．94％）；其中酵母样真菌对两性霉素B和制霉菌素无耐药性，铜绿假单胞菌、变形菌属和克雷伯菌属对美罗培南和亚胺培南无耐药性，80％的金黄色葡萄球菌为耐甲氧西林金黄色葡萄球菌（MRSA），且对米诺环素、呋喃妥因、夫西地酸、万古霉素、替考拉宁和喹奴普汀-达福普汀无耐药性。结论在治疗不同原因菌引起的Ⅲ度菌群失调及内源性感染过程中，只有选择不同的敏感药物，才能去除可以去除的特异性病原因子。
OBJECTIVE To understand the drug resistance of causative bacteria from the intestinal tract dysbacteriosis of the iatrogenic diarrhea patient, and to provide basis for choose the medicine for the clinical treatment of Ⅲ degree intestinal tract dysbacteriosis and internal infection caused by different causative bacteria. METHODS VITEK-ATB system was used to analyze and calculate the causative bacteria and their drug resistance from the intestinal tract dysbacteriosis of the iatrogenic diarrhea patient in the hospital from 2001 to 2003. RESULTS Causative bacteria for intestinal tract dysbacteriosis in order were enterococci （31.90%）, yeast-like fungi（ 27.24%）, Proteus （ 16.34%）, Pseudomonas aeruginosa （ 6.23%）, Citrobacter （ 5.84%）, Klebsiella （5.45%）, toxin A producing Clostridium difficile （5.06%）, and Staphylococcus aureus （1.94%）. The yeastlike fungi had no drug resistance to amphotericin B and nystatin, the P. aeruginosa, Proteus and Klebsiella had no drug resistance to imipenem and meropenem, 80% S. aureus were MRSA, and had no drug resistance to minocycline, nitrofurantoin, fusidic acid, vancomycin, teicoplanin and quinupristin-dalfopristin. CONCLUSIONS In the process of treatment m degree intestinal tract dysbacteriosis and interior-infection caused by different causative bacteria, choosing different sensitive medicine could remove the specific causative factors of the disease.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第1期83-85,共3页
Chinese Journal of Nosocomiology
关键词
菌群失调
细菌
毒素
药物耐受性
治疗
Dysbacteriosis
Bacteria
Toxin
Drug tolerance
Treatment
