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Local signals in stem cell-based bone marrow regeneration 被引量:17

Local signals in stem cell-based bone marrow regeneration
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摘要 The cellular basis of bone marrow (BM) tissue development and regeneration is mediated through hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Local interplays between hematopoietic cells and BM stromal cells (BMSCs) determine the reconstitution of hematopoiesis after myelosuppression. Here we review the BM local signals in control of BM regeneration after insults. Hematopoietic growth factors (HGFs) and cytokines produced by BMSCs are primary factors in regulation ofBM hematopoiesis. Morphogens which are critical to early embryo development in multiple species have been added to the family of HSCs regulators, including families of Wnt proteins, Notch ligands, BMPs, and Hedgehogs. Global gene expression analysis of HSCs and BMSCs has begun to reveal signature groups of genes for both cell types. More importantly, analysis of global gene expression coupled with biochemical and biological studies of local signals during BM regeneration have strongly suggested that HGFs and cytokines may not be the primary local regulators for BM recovery, rather chemokines (SDF- 1, FGF-4) and angiogenic growth factors (VEGF-A, Ang- 1) play instructive roles in BM reconstitution after myelosuppression. A new direction of management of BM toxicity is emerging from the identification of BM regenerative regulators.
出处 《Cell Research》 SCIE CAS CSCD 2006年第2期189-195,共7页 细胞研究(英文版)
关键词 bone marrow REGENERATION hematopoietic stem cells mesenchymal stem cells signaling molecules MYELOSUPPRESSION 干细胞 骨髓再生 病理机制 间叶细胞
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  • 1Wilkins BS. Histology of normal haemopoiesis: bone marrow histology Ⅰ. J Clin Pathol 1992; 45:645-9.
  • 2Moore MSA, Metcalf D. Ontogeny of the haemopoietic system:Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 1970; 18:279-96.
  • 3Cheshier SH, Morrison S J, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A 1999;96:3120-5.
  • 4Weissman IL. Translating stem and progenitor cell biology to the clinic: Barriers and opportunities. Science 2000; 287:1442-6.
  • 5Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404:193-7.
  • 6Fuchs E, Segre JA. Stem cells: A new lease on life. Cell 2000;100:143-55.
  • 7Morrison S J, Shah NM, Anderson DJ. Regulatory mechanisms in stem cell biology. Cell 1997; 88:287-98.
  • 8MetcalfD. Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: Influence of colony-stimulating factors. Proc N atl Acad Sci U S A 1991; 88:11310-4.
  • 9Mayani H, Dragowska W, Lansdorp PM. Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines, J Cell Physiol 1993; 157:579-86.
  • 10Willert K, Brown JD, Danenberg E, et aL Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003;423:448-51.

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