摘要
目的测定脑囊虫病患者血清和脑脊液IL-6和SIL-2R水平,并探讨其与癫痫发作的关系。方法应用双抗体夹心ELISA法测定45例脑囊虫病患者和43例对照组患者血清和脑脊液IL-6利SIL-2R的水平,其中脑囊虫病组又分为癫痫组(23例)和非癫痫组(22例),分别进行了比较分析。结果脑囊虫病组血清SIL-2R水平明显高于对照组(P<0.05);而IL-6水平与对照组比较无显著性差异(P>0.05)。脑囊虫病组脑脊液SIL-2R和IL-6水平均较对照组低(P<0.01,P<0.05);脑囊虫病组血清SIL-2R和IL-6水平与脑脊液SIL-2R和IL-6水平均呈正相关(r=0.322,P<0.05;r=0.768,P<0.01)。脑囊虫病癫痫组血清SIL-2R和IL-6水平与非癫痫组比较均无显著性差异(P>0.05);而脑脊液SIL-2R和IL-6水平癫痫组明显高于非癫痫组(P<0.01)。结论脑囊虫病患者外周血和中枢神经系统存在免疫激活,且SIL-2R和IL-6可能参与了癫痫发生过程。
Objective： To investigate the concentration of SIL-2R and IL-6 in paired serum and cerebrospinal fluid（CSF） from 45 patients with cerebral cysticercosis, and to evaluate the relation with epilepsy seizures. Methods： SIL-2R and IL-6 were measured by ELASA ill paired serum and CSt： from 45 patients with cerebral eysticercosis and 43 references. The patients were divided into two groups according to clinical manifestations： epilepsy and nonepilepsy group. Results： The SIL-2R level in the serum of neurocysticercosis patients was obviously higher than that of control group （P〈0.05） ; in the CSF, SIL-2R and IL-6 levels are lower than controls （P〈0.05） ; in neurocysticercosis group, SIL-2R and IL-6 levels of serum have positive correlations with those of CSF（separately r= 0.322 and r= 0. 768, P〈0.05） ; in CSF of the epilepsy group, SIL-2R and IL-6 levels are higher than the nonepilepsy group （P〈0.01）. Conclusions： In neurocysticercosis patients, the immune and inflammation response SIL-2R and IL-6 maybe participate in the happening process of epilepsy.
出处
《脑与神经疾病杂志》
2006年第1期13-15,共3页
Journal of Brain and Nervous Diseases
