摘要
目的探讨临床相关因素与骨肉瘤患者无瘤生存预后的关系。方法对40例ⅡB期骨肉瘤术后无瘤生存情况进行随访,应用等级相关分析以及COX回归模型多因素分析方法研究临床相关因素与骨肉瘤患者无瘤生存率及生存时间的关系。结果患者的性别、年龄、病程、血清碱性磷酸酶及手术方式(保肢与截肢)与无瘤生存率无关(P>0.05);术前化疗组与术前未化疗组累计无瘤生存率无显著性差异(P>0.05);术后化疗组累计无瘤生存率高于术后无化疗组(Log-R ank检验,P=0.0067)。多因素分析显示,术后化疗是影响无瘤生存预后的独立因素(P=0.014)。结论术后化疗有助于提高骨肉瘤患者术后无瘤生存率,术前化疗与无瘤生存率的关系尚需进一步研究。
Objective： To study the clinical prognostic factors on disease-free survival of osteosarcoma. Methods： 40 patients with stage IB osteosarcoma who had completed follow-up data were chosen for disease-free survival analysis, Spearman analysis and Cox model were used for analyses of relationships of clinical factors with disease-free survival rate. Results： According to single variate analysis, age, gender, course of disease, AKP levels, surgeries （limb-salvage or amputation）and preoperative chemotherapy did not correlate with prognosis of disease-free survival（ P〉0. 05）, postoperative adjuvant chemotherapy statistically correlated with disease-free survival （Log-Rank test, P= 0. 0067）. Multivariate analysis showed that only the postoperative chemotherapy （ P=0. 014） was the independent prognostic factor of disease-free survival. Conclusions： Postoperative chemotherapy may increase the postoperative disease-free survival rate of osteosarcoma. More cases are necessary for further study of the relationship between preoperative chemotherapy with disease-free survival of osteosarcoma.
出处
《山东医药》
CAS
北大核心
2006年第3期6-7,共2页
Shandong Medical Journal
