摘要
目的:评价含力克肺疾(D)、左氧氟沙星(L)和吡嗪酰胺(P)和阿米卡星(A)的四联化疗方案治疗耐药物性肺结核的临床疗效。方法:选取耐多药肺结核患者128例,治疗组66例采用3DLPA/15DLP方案,对照组62例采用3PtPaOK/15PtPaO方案(Pt:丙硫异烟胺;Pa:对氨基水杨酸;O:氧氟沙星;K:卡那霉素)。结果:治疗18个月后,治疗组痰菌阴转率、病灶吸收好转率明显高于对照组(P<0.05)。结论:含力克肺疾(D)、左氧氟沙星(L)和吡嗪酰胺(P)和阿米卡星(A)的四联化疗方案治疗耐药物性肺结核的临床疗效优于对照组,适用于耐多药肺结核的治疗。
Objective： To evaluate the therapentic effect of Pasiniazide（Dipasic, D）, Levofloxaein（L）, Pyrazinamide（P） and Amikacin（A） combined in treating multidrug- resistant tuberculosis. Methods： 128 patients with multidrug - resistant tuberculosis were randomly divided into the treatment group （66 eases）, treated with the schema of 3D- LPA/15DLP, and the control group （62 cases）, treated with 3PtPaOIG 15PtPaO （Pt： Prothionamide; Pa： Para-aminosalicylate; O： Ofloxaein; K： Kanamyein）. Results： After 18- month treatment, the negative- conversion rates of sputum and loci absorption rates in the therapeutic group were much higher than those of the control group （ P 〈 0.05）. Conclusion： The prescription combining 4 drags, i. e： Pasiniazide, Levofloxaein, Pyrazinarnide and Amikacin, is superior to the control group, and it is effective for treating the muhidrug- resistant tuberculosis.
出处
《泸州医学院学报》
2006年第1期38-39,共2页
Journal of Luzhou Medical College
关键词
耐多药结核
化疗
Multidrug- resistant tuberculosis
Chemotherapy
