摘要
目的探讨褪黑素对急性脑梗死患者免疫受损恢复的干预作用。方法将60例入选的急性脑梗死患者随机分为褪黑素(Melatonin,MT)干预组和维生素C对照组,另在健康查体者中选30人作正常对照组。急性脑梗死患者于发病后第3天开始分别给与MT(9mg/d,每晚临睡前口服1次)片和维生素C片(0.3/d,每晚口服1次),用流式细胞仪(FCM)直接荧光染色法检测发病后第3天和给药后第14天的外周血CD3+、CD4+、CD8+T淋巴细胞数量,并统计两组的感染率。结果维生素C对照组第14天的CD3+、CD4+和CD4+/CD8+均较正常对照组明显降低(P<0.01),而MT干预组第14天的CD3+、CD4+和CD4+/CD8+与正常对照组比较无显著差异(P=0.25),但与维生素C对照组比较有显著性差异(P<0.01)。与维生素C对照组相比,MT组的感染并发症较少(P<0.01)且较轻。结论适当补充MT能扭转或改善急性脑梗死受损的T细胞免疫功能,减少感染并发症的发生。
Objective To explore intervention of Melatonin （MT） on the impaired immunity of the patients suffered from acute cerebral infarction （ACI）. Methods The 60 selected ACI patients were divided randomly into MT group and Vitamin C group, and 30 healthy persons were selected as healthy control group. Tablets of MT （9mg,oral admlnistration,1 time/night） and Vitamin C（0.3,oral administration, 1 time/night） were given respectively from the third day after the onset of ACI and the numbers of CD3^＋,CD4^＋ and CD8^＋ T lymphocyte in peripheral blood were examined with flow cytometry （FCM,with direct immunofluroscent staining technique） on the day before the intervention and on the 14th day after intervention,Results The number of CD3^＋,CD4^＋ and ratio of CD4^＋/CD8^＋ in Vitamin C group on the 14th day were significantly lower than those in healthy control group and in MT group （P〈0.001）, but there was no difference between MT group and healthy control group （P=0.25）. Moreover, the cases complicated with infection in MT group were less than those in Vitamin C group （P〈0.001）and they were often less serious.Conclusion The moderate supplement of MT can reverse or improve the damaged T cell immunity of the ACI patients and decrease the incidence of the infective complications in them.
出处
《实用医药杂志》
2006年第2期150-152,共3页
Practical Journal of Medicine & Pharmacy
关键词
褪黑索
急性脑梗死
T淋巴细胞亚群
干预作用
Melatonin Acute cerebral infarction T lymphocyte subpopulation Intervention
