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绞股蓝总甙对大鼠实验性高脂血症的影响 被引量:6

THE EFFECTS OF GYPENOSIDE ON EXPERIMENTAL HYPERLIPIDEMIA IN RATS
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摘要 本文观察了绞股蓝总甙(gypenoside,Gyp)对大鼠高脂血症(hyperlipidemia,HPL)的影响。结果显示:Gyp(150mg/kg·d)显著降低高脂血症大鼠血清总胆固醇(TC),甘油三酯(TG)水平,提高高密度脂蛋白(HDL)浓度;使肝脏,主动脉壁TC含量下降。实验还发现Gyp能降低HPL大鼠血和肝脏过氧化脂质(lipidperoxides,LPO)水平,提高超氧化物歧化酶(su-peroxidedismutase,SOD)活性。提示:Gyp具有降脂保肝,预防动脉硬化形成的作用,此作用可能与Gyp减少过氧化脂质对肝细胞和动脉内皮细胞的损害有关。 After the rats with hyperlipidemia were orally treated with the gypenoside(150mg/kg·d)for 12 weaks the blood levels of TC and TG were significantly decreased,and the con-centration of HDL was greatly increased.The contents of TC in the rats liver and aortic wall werealso significantly decreased.It was also found that the concentration of LPO in serums and liversof the rats with hyperlipidemia was markedly reduced by gypenoside,but the activity of SOD waselevated.From results obtained,it is suggested gypenoside possessed the therapeutic on hyperlipi-demia together with hepaticdernage and atherosclerosis.
出处 《河南医学研究》 CAS 1996年第2期113-116,共4页 Henan Medical Research
关键词 绞股蓝总甙 高脂血症 药理学 gypenoside(Gyp),hyperlipidemia(HPL),atherosclerosis,lipid peroxide(LPO),superoxide dismutase(SOD)
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参考文献4

  • 1石琳,范盘生,吴玲,杨健.川芎嗪对实验性高脂血症家兔的抗脂质过氧化及升高动脉壁前列环素作用[J].中药药理与临床,1989,5(5):18-21. 被引量:5
  • 2丛学滋,秦孟根,李琦,卜乃钊,李子行,戴德哉.苜蓿皂甙的降血胆固醇及减轻实验性动脉粥样硬化形成的作用[J]中国药理学通报,1988(05).
  • 3邹国林,桂兴芬,钟晓凌,朱汝璠.一种SOD的测活方法——邻苯三酚自氧化法的改进[J]生物化学与生物物理进展,1986(04).
  • 4陈顺志,金有余,李常淳,张增权.过氧化脂质TBA显色的三种方法学比较[J]临床检验杂志,1984(04).

二级参考文献2

  • 1范盘生,石琳.三七总皂甙、人参果总皂甙对老年大鼠心脑组织脂褐质及血清过氧化脂质含量的影响[J]中国药理学与毒理学杂志,1988(04).
  • 2石琳,范盘生,梁中琴,方几希,韩志新.川芎嗪抑制动脉粥样硬化斑块形成及其机制分析[J]中药药理与临床,1988(02).

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