摘要
前列腺素D2(PGD2)是由前列腺素D2合成酶合成的一种二十碳不饱和脂肪酸。研究表明PGD2具有睡眠调节作用,其机理为PGD2与前列腺素D2受体结合,升高基底前脑部位细胞外腺苷水平。腺苷通过腺苷A2A受体激活睡眠调节中枢(腹外侧视前区,VLPO)神经元,并通过GABA抑制觉醒调节中枢(结节乳头核,TMN)组胺能神经元而导致睡眠。对PGD2睡眠调节作用及其机理进行研究,有望开发出新型的镇静催眠药物。
Prostaglandin （PG） D., is one of unsaturated fatty acids with 20 carbon atoms, which is synthesized by PGD synthase （PGDS） in the brain. PGD2 has been identified to be a sleep-inducing substance that becomes bound to the DP receptor （DPR） exclusively localized on the surface of the basal forebrain, leading to an increase in extracellular adenosine levels there. Through A2A receptors （A2A R）, the adenosine activates neurons in the ventrolateral preoptic area （VLPO）, a putative sleep center, and inhibits neurons in the histaminergic tuberomammillary nucleus （TMN）, a putative wake center, via GABA to induce sleep. Studying the effect and the molecular mechanisms of sleep-induced by PGD2 would be helpful in the development of novel sleeping drugs for more rational treatment of sleep disorders.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第12期1321-1325,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
皖南医学院博士科研启动资金资助
