摘要
目的:研究视网膜母细胞瘤组织中Bcl-2,p16和PCNA的表达方法:视网膜母细胞瘤标本36例采用免疫组织化学方法观察Bcl-2,p16和PCNA表达水平。结果:Bcl-2,p16和PCNA阳性检出率分别是55.6%,47.2%,61.1%,分化型与未分化型之间比较差异有显著性(P<0.01)。结论:Bcl-2,p16和PCNA在视网膜母细胞瘤的产生和发展过程中起重要作用。
AIM： To investigate the correlation of Bcl-2,p16 and proliferating cell nuclear（PCNA） in retinoblastoma.
METHODS： Immunohistochemical staining was used to determine the expression of the p16, Bcl-2 and PCNA in 36 samples of Retinoblastoma.
RESULTS： The positive expression rates of the Bd-2, p16 and PCNA in retinoblastoma were 55.6%, 47.2%, 61.1% respectively. There was a significant difference in differentiated and undifferentiated types （P〈0.01）.
CONCLUSION： The results suggest that Bcl-2, p16 and PCNA play an important role in the genesis and progression of retinoblastoma.
出处
《国际眼科杂志》
CAS
2005年第6期1172-1174,共3页
International Eye Science
