摘要
目的：探讨大剂量甲基强的松龙(MP)在脊髓型颈椎病患者围手术期应用的价值。方法：脊髓型颈椎病患者125例。分为3组，A组：术后未用激素治疗组，42例；B组：氟美松治疗组，38例；C组：大剂量MP+抗酸药组，45例。比较三组患者手术前后的神经功能评分(JOA 17分法)，统计并发症，观察患者术后咽部不适的时间。结果：3组患者术前、术后1周及术后3个月的JOA评分比较无显著性差异；C组患者术后无症状反跳现象，术后咽部不适的时间明显短于A、B两组(P＜0．001)；A组发生1例伤口感染，B组出现1例消化道隐性失血，C组出现1例毛囊炎、2例消化道隐性失血。结论：大剂量甲基强的松龙可以改善脊髓型颈椎病患者术后咽部不适的症状，应用安全，但对神经功能恢复无明显作用。
Objective：To investigate the effects of postoperative high dose mythylprednisolone （MP） on the patients of cervical spondylotic myelopathy（CSM） undergoing cervical spine surgery.Method：125 cases of CSM undergoing cervical spine surgery were divided to three groups,group A （control）：42 cases,group B（dexam ethasone sodium phosphate）：38 cases,group C （high dose methylprednisolone＋ranitidine）：45 cases.Comparison of neurological function by JOA was observed.Postoperative pharyngolaryngeal lesions and other complications were also analyzed.Result：Statistical analysis showed that postoperative high dose MP did not influence the outcome of CSM patients undergoing cervical spinal surgery （P〉0.05）,but can reduce extent of postoperative reperfusion lesions and pharyngolaryngeal lesions （P〈0.01）.Complications such as gastrointestinal bleeding and wound infections were not observed.Conclusion：High dose MP used postoperatively on CSM patients can reduce extent of postoperative reperfusion lesions and pharyngolaryngeal lesions.The usage of MP mentioned above is safe.
出处
《中国脊柱脊髓杂志》
CAS
CSCD
2005年第12期713-715,共3页
Chinese Journal of Spine and Spinal Cord
关键词
甲基强的松龙
脊髓型颈椎病
手术
Methylprednisolone
Cervical spondylotic myelopathy
Operation
