摘要
目的探讨预防单纯型过敏性紫癜肾损害的有效方法.方法将146例单纯型过敏性紫癜患儿分为两组,实验组82例,在行常规治疗的基础上,给予低分子右旋糖酐5ml/(kg·d)和小剂量肝素钠0.5mg/(kg·d),静脉滴注治疗,共2～3周.对照组64例,仅行常规治疗.两组患儿均于治疗前、用药期间及用药结束后每周检测1次尿微量蛋白β2-MG和Alb,直到发病后3个月.观察比较两组治疗前后尿微量蛋白β2-MG和Alb的变化.结果实验组患儿治疗后尿微量蛋白β2-MG和～b明显低于对照组(t＞2.58,P＜0.01),证明实验组患儿发生肾损害的机率明显低于对照组.结论联合应用低分子右旋糖酐和小剂量肝素静脉滴注可有效地防止小儿过敏性紫癜肾损害的发生.
Objective to explore an effective treatment for simple purpura nephropathy. Methods 146 cases of simple purpura nephropathy were divided into two groups. The experimental group of 82 cases was treated with low molecular dextran of 5ml/（kg·d）, and a low dose of heparin sodium of 0.5mg/（kg· d） in intravenous drips for 2- 3 weeks in addition to the routine treatment. The contrast group of 64 cases was treated wtih routine medhods alone. The contents of β2 - MG and Alb were detected weekly in both groups before, during and after the treatments. The detections lasted three months. The contents of β2 - MG and Alb of the two groups before and after the treatments were compared. Results The contents of β2 - MG and Alb were found much lower in the experimental group than in the contrast group （ t 〉2.58, P 〈 0.01）, which proved that the incidence of purpura nephropathy was much lower in the experimental group than in the contrast group. Conclusion Combination of low molecular dextran and a low dose of heparin sodium can effectively reduce the incidence of purpura nephropathy.
出处
《临沂医学专科学校学报》
2005年第6期411-413,共3页
Journal of Linyi Medical College
