期刊文献+

儿童消化性溃疡药物治疗的临床研究 被引量:6

The clinical trial on the treatment of pediatric peptic ulcer.
下载PDF
导出
摘要 【目的】比较不同方案治疗儿童消化性溃疡(peptic ulcer,PU)的疗效和幽门螺杆菌(helicobacter pylori,Hp)的根除率,并评价根除Hp在儿童PU愈合中的作用。【方法】80例Hp感染伴PU的患儿分两组接受治疗。A组奥美拉唑0.8 mg/(kg.d)顿服,疗程2周;B组胶体枸橼酸铋8 mg/(kg.d),每日分3次口服,疗程2周。上述两组同时加服阿莫西林50 mg/(kg.d)和甲硝唑15 mg/(kg.d),均分为3次口服。【结果】溃疡的愈合率A组91.67%(4 4/4 8),B组7 5.0 0%(2 4/3 2);Hp的根除率A组8 3.3 3%(4 0/4 8),B组5 6.2 5%(1 8/3 2);Hp根除者溃疡愈合率96.56%,未根除者愈合率54.55%,差异有显著性(P<0.01)。【结论】质子泵抑制剂奥美拉唑加两联抗生素组成的三联疗法治疗儿童Hp感染的消化性溃疡具有疗效高的优点,根除Hp可以提高儿童PU的愈合率。 [Objectives] To observe the effect of different therapy in the management of peptic ulcer and the eradicative rate Helicobacter pylori. [Methods] 80 patients with pediatric Helicobacter pylori peptic ulcer were divided into 2 groups. Group A was treated with Omeprazole 0. 8mg/(kg · d) for 2 weeks, group 13 with CBS 8 mg/(kg · d) for 2 weeks. Amoxycillin 50 mg/(kg · d) and metronidazol were adrnindstered to all the groups. [Results] 91.67%(44/48) of peptic ulcer in group A,75.00%(24/32) in group B. 83.33%(40/48) of Helicobacter pylori in group A, 56.25%( 18/ 32 ) in group B were eradicated. 96. 56 % of the peptic ulcer were cured in patients Helicobacter pylori eradicated , while 54.55% in uneradicated. [Conclusion] Proton pump inhibitor(Omeprazole) in combination with antibiotics is showed more efficient therapeutic effect, Helicobacter pylori eradication can improve the pediatric peptic ulcer cure rate.
出处 《中国儿童保健杂志》 CAS 2006年第1期29-30,共2页 Chinese Journal of Child Health Care
关键词 幽门螺杆菌 儿童 消化性溃疡 药物 helicobacter pylori child peptic ulcer drug
  • 相关文献

参考文献9

二级参考文献29

  • 1戈之铮,张德中,萧树东,陈颖,胡运彪.根除幽门螺杆菌治疗十二指肠溃疡的随机对照研究[J].胃肠病学,1999,4(4):234-236. 被引量:6
  • 2吴志伟,李建平,何金海,江志红.大尺度大气环流异常与长江中下游夏季长周期旱涝急转[J].科学通报,2006,51(14):1717-1724. 被引量:92
  • 3萧树东.消化性溃疡[M].见:叶任高主编.内科学 第五版[C].北京:人民卫生出版社,2002.398-399.
  • 4杨雪松 李益农.幽门螺杆菌感染的呋喃唑酮治疗[M].见:胡伏莲主编.幽门螺杆菌感染的基础与治疗[C].北京:中国科技出版社,1997.428-430.
  • 5Soll All. Medical treatment of peptic ulcer disease. Practice guidelines[J].JAMA,1996,622-629.
  • 6Malfertheiner P, Megraud F, O′Morain C, et al. European Helicobacter Pylori Study Group (EHPSG). Current concepts in the management of Helicobacter pylori infection: the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther,2002 ,16:167-180.
  • 7孙明.价效医学应予重视[J].中华内科杂志,2001,40(1):5-5.
  • 8胡伏莲 贾博琦 谢鹏雁.用抗生素治疗合并幽门螺杆菌感染的难治性十二指肠溃疡[J].中华消化杂志,1988,27(4):205-205.
  • 9Ling TK,Cheng AF,Sung JJ,et al.An increase in Helicobacter pylori strains resistant to metronidazole: a five-year study[].Helicobacter.1996
  • 10Vakil N,Hahn B,McSorley D.Clarithromycin-resistant Helicobacter pylori in patients with duodenal ulcer in the United States[].The American journal of Gastroenterology.1998

共引文献669

同被引文献13

引证文献6

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部