摘要
谷氨酸是中枢神经系统中含量最丰富的兴奋性神经递质,而肝性脑病的发生与氨过多、神经递质功能失衡有关。肝性脑病患者及动物模型中谷氨酸神经递质功能不良,其受体结合位点减少甚至缺失。患肝性脑病时,血氨影响谷氨酸受体功能与代谢,使谷氨酸受体与肝性脑病脑细胞功能紊乱有一定关系。
Glutamate is the most abundant excited neurotransmitter in the central nervous system , the occurrence of hepatic encephalopathy is relevant to excessive ammonia and disbanlanee of neurotransmitter function. In the patient and the animal model of hepatic encephalopathy, the function of glutamate neurotransmitter is bad, and receptor binding site is reductive and even lack. While suffering from hepatic encephalopathy, the blood ammonia affects the function and metabolisms of glutamate receptor, which makes glutamate receptor have some relationship with brain cell function mess in hepatic enccphalopathy.
出处
《医学综述》
2006年第3期175-176,共2页
Medical Recapitulate
关键词
谷氨酸
肝性脑病
受体
血氨
Glutamate
Hepatic enccphalopathy
Receptor
Blood ammonia
