摘要
目的观察银虎汤治疗进行期寻常性银屑病的临床疗效及其对血清IL-8的影响。方法选取进行期寻常性银屑病患者78例,随机分为治疗组45例和对照组33例,分别采用银虎汤和复方青黛胶囊,并选取健康志愿者12例为正常组,观察治疗组和对照组及正常组血清IL-8水平,治疗组和对照组临床疗效、PASI值及治疗前后血清IL-8水平比较。结果进行期寻常性银屑病患者血清IL-8水平高于正常对照组(P<0.01),治疗组和对照组临床总有效率分别为91.11%、72.73%,对比有显著差别(P<0.05),治疗前后治疗组血清IL-8水平明显下降(P<0.01),PASI值明显下降(P<0.01)。结论银虎汤治疗进行期寻常性银屑病疗效确切,可降低PASI值和血清IL-8水平。
Objective： To investigate the clinical effect of Yinhu decoction treating progressing psoriasis vulgaris （PVP） patients , objectively evaluate the serum level of IL-8 in PVP and the effect of Yinhu decoction. Methods： 78 PVP patients were randomly divided into treated group （n=45） and control group （n= 33）, they were treated with Yinhu decoction and compound Qingdai capsule respectively. 12 healthy persons subjects were selected as normal control. The serum level of IL-8 in all patients and healthy person subject as well as clinical therapeutical effect of the treatment and the psoriasis area and severity index （PASI） were observed and compared. Results： The 8 weeks＇ total effective rate in treated group and control group were 91.11% and 72. 73% respectively. Comparison between them showed significant difference （P〈0. 05）. Serum level of IL-8 in the patients before treatment were higher than that in healthy subjects （P〈0.01） ;after 8 weeks＇treatment, it lowered significantly in the treated group （P〈0. 05）. The PASI were lowered （P〈0. 01）. Conclusion： Yinhu decoction has certain clinical effect in treating PVP, it could lower PASI and the serum level of IL-8.
出处
《湖北中医学院学报》
2005年第3期49-50,共2页
Journal of Hubei College of Traditional Chinese Medicine
