期刊文献+

Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy 被引量:1

Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy
下载PDF
导出
摘要 A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response. A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第45期7218-7221,共4页 世界胃肠病学杂志(英文版)
关键词 Hepatocellular carcinoma INTERFERON HCV ERADICATION 肝细胞癌 丙型肝炎病毒 干扰素 治疗
  • 相关文献

二级参考文献11

  • 1Sabine Mihm PhD,Heinz Hartmann MD,Afshin Fayyazi MD,Prof. Dr. Giuliano Ramadori MD.Preferential virological response to interferon-α 2a in patients with chronic hepatitis C infected by virus genotype 3a and exhibiting a lowγ-GT/ALT ratio[J].Digestive Diseases and Sciences.1996(6)
  • 2Shiffman ML.Management of hepatitis C[].Clin Perspect Gastroenterol.1998
  • 3Pagliaro L,Peri V,Linea C,Cammà C,Giunta M,Magrin S.Natural history of chronic hepatitis C[].Italian Journal of Gastroenterology and Hepatology.1999
  • 4Ben-Ari Z,Tur-Kaspa R.New trends in liver transplantation for viral hepatitis[].The American journal of Gastroenterology.1997
  • 5Hoofnagle JH,Mullen KD,Jones DB,Rustgi V,Di Bisceglie AM,Peters M,Waggoner JG.Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon: a preliminary report[].The New England Journal of Medicine.1986
  • 6Lindsay KL.Therapy of hepatitis C: Overview[].Hepatology.1997
  • 7Connor E,Morrison S,Lane J,Oleske J,Sonke RL,Connor J.Safety, Tolerance, and pharmacokinetics of systemic ribavirin in children with human immunodeficiency virus infection[].Antimicrobial Agents and Chemotherapy.1993
  • 8Roberts RB,Laskin OL,Laurence J,Scavuzzo D,Murray HW,Kim YT,Connor JD.Ribavirin pharmacodynamics in high-risk patients for acquired immunodeficiency syndrome[].Clinical Pharmacology and Therapeutics.1987
  • 9Glue P.The clinical pharmacology of ribavirin[].Seminars in Liver Disease.1999
  • 10Di Bisceglie AM,Coujeevaram HS,Fried MW.Ribavirin as therapy for chronic hepatitis C[].Annals of Internal Medicine.1995

共引文献18

同被引文献2

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部