摘要
目的探讨抗精神病药合并盐酸丁咯地尔治疗Ⅱ型精神分裂症的临床疗效与IL-2和IL-6水平的变化。方法Ⅱ型精神分裂症患者共68例,随机分为研究组与对照组,研究组采用抗精神病药和盐酸丁咯地尔治疗,而对照组则单用抗精神病药治疗,治疗时间均为4周,采用简明精神病评定量表(BPRS)、阴性症状量表(SANS)、阳性症状量表(SAPS)来评定患者治疗前后症状的改变,用BPRS减分率来评价临床疗效,同时测定治疗前后IL-2、IL-6水平。结果治疗后研究组BPRS(26.33±2.54)分、SANS(16.29±3.57)分、SAPS(1.43±1.69)分,分值较对照组有明显下降(P<0.05),临床疗效则有明显提高(P<0.05),且IL-2[(10.57±9.43)pg/ml]和IL-6[(10.38±6.81)pg/ml]水平有明显下降(P<0.05)。结论合并盐酸丁咯地尔有助于提高阴性精神分裂症患者的临床疗效,降低细胞因子水平。
Objective To study the therapeutic effect and the change of IL-2 and IL-6 of antipsychotic with Buflomedil Hydrochlorde for the treatment of Ⅱ-type schizophrenia. Methods 68 schizophrenic with negative symptoms were divided into the experiment group and the control group in random, and treated with antipsychotic or antipsychotic with Buflomedil Hydrochlorde for 4 weeks. All patients were assessed in pretreatment and post-treatment by Brief Psychiatric Rating Scale （BPRS）, Scale for the Assessment of Negative Symptoms （SANS） ,Scale for the Assessment of Positive Symptoms （SAPS）. The clinical effect was evaluated by decrease scale rating of BPRS. All patients were tested the level of IL-2 and IL-6 in pretreatment and post-treatment. Results After treatment, there was significant differ ent （ P 〈 0.05） in total score of BPRS （26.33±2.54）, SANS （16.29±3.57）, SAPS （ 1.43±1.69）, clinical effect and the level of IL-2 （ 10.57 ＋ 9.43 ） and IL-6 （10.38±6.81 ） between the experiment group and the control group. Conclusion Antipsychotic combined witt, Buflomedil Hydrochlorde help to improve the curative efficiency of schizophrenia sufferer, and decrease the level of IL-2 and IL-6.
出处
《中国行为医学科学》
CSCD
2006年第2期131-133,共3页
Chinese Journal of Behavioral Medical Science
