摘要
哺乳动物胚胎附植前期包括:合子的形成,胚胎基因组的激活和细胞分化的开始。在这个时期,发育由母源物质控制转为合子基因控制,在此过程,同时形成染色质介导的转录抑制时期,要解除抑制必须经过胚胎基因组的激活。通过对体内、外附植前胚胎的mRNA的表达特点以及它们与成功发育联系的研究,可以筛选出最佳的体外培养条件,设计最佳的核移植方案。
The pre-implantation period of mammalian development includes the formation of the zygote, the activation of the embryonic genome（EGA）, and the beginning of cellular differentiation. During this period, the maternal control of development is succeeded by zygotic control, and the formation of a chromatin-mediated transcriptionally repressive state is beginning. For relieving this repressiveness, the embryonic genome is activated. The characterization of zygotic mRNA expression patterns during the pre-implantation period and their relationship tosuccessful development in vitro and in vivo will be essential for defining optimized culture conditions and nuclear transfer protocols.
出处
《中国畜牧杂志》
CAS
北大核心
2006年第1期64-67,共4页
Chinese Journal of Animal Science
基金
国家自然科学基金资助(30100133)
关键词
畜牧学
附植前胚胎
综述
基因表达
胚胎基因组激活
animal science
pre-implantation embryo
@review
gene expression
activation of the embryonic genome
