抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义被引量：10

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摘要目的对疑似类风湿关节炎的患者,进行抗环瓜氨酸肽及类风湿因子(RF)联合检测,以提高疾病的诊断率。方法抗环瓜氨酸肽抗体(简称抗CCP抗体)检测采用ELISA法,类风湿因子采用散射速率比浊法,对163例早期疑似患者和67例患病2年以上的类风湿关节炎患者进行对照检测。结果抗CCP抗体、RF及两者联合检测在早期疑似患者中的阳性率分别为46.01%、55.21%和69.94%;抗CCP抗体、RF及抗CCP,抗体和RF联合检测在患病2年以上患者中的阳性率分别为46.27%、53.73%、73.13%。经过统计学分析联合检测与单项检测比较有统计学意义(P<0.01或P<0.05)。结论抗CCP抗体和RF两种试验联合检测可明显提高类风湿性关节炎的诊断率。

作者唐吉斌孙芸陈继忠张大昌

机构地区安徽省铜陵市人民医院检验科

出处《检验医学与临床》 CAS 2006年第1期12-12,14,共2页 Laboratory Medicine and Clinic

关键词抗环瓜氨酸肽抗体类风湿因子类风湿性关节炎

分类号 R446.6 [医药卫生—诊断学] R593.22 [医药卫生—内科学]

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