摘要
目的:制备并鉴定桉油β-环糊精包合物,以证实应用包合技术改进桉油剂型的可行性。方法:分别采用薄层层析法(TLC)、红外光谱法(IR)、紫外分光光度法(UV)及气-质联用法(GC-MS)对包合物进行理化鉴别,考察桉油在加入β-环糊精包合前、后的成分变化和包合效果。结果:TLC、IR、UV分析结果均显示桉油与β-环糊精已形成了稳定的包合物;GC-MS分析结果显示包合前、后桉油的的主要成分及含量无明显变化。结论:桉油能与β-环糊精形成稳定包合物,且包合过程不影响其成分组成及含量。
OBJECTIVE- To prepare and appraise eucalyptus oil β- cyclodextrin inclusion compound, and to testify the feasibility of transforming the dosage form of eucalyptus oil by clathration techniques. METHODS： The physieochemical properties of inclusion compound was identified by thin layer chromatography （TLC）, infrared spectroscopy （IR）, ultra violet spectroscopy （UV） and gas chromatograph mass spectrometer （GC MS）, respectively. Meanwhile, the changes in constituents and clathration outcomes of eucalyptus oil before and after clathration were also investigated. RESULTS： The analytic result of TLC, IR and UV showed that stable inclusion compound has been formed from eucalyptus oil and β-cyclodextrin. The result of GC MS demonstrated that therc was no significant change in the essential components and the percentage composition of eucalyptus oil before and after inclusion. CONCLUSION- Stable inclusion compound can be made from eucalyptus oil and β- cyclodextrin meanwhile without changes in main components and the percentage composition of eucalyputus oil.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第4期255-258,共4页
China Pharmacy
基金
国家自然科学基金资助项目(30300456)
关键词
桉油
Β-环糊精
包合物
制备
鉴定
Eucalyptus oil
β cyclodextrin
Inclusion compound
Preparation
Identification
