摘要
以对硝基甲苯为原料,经溴化、氟置换、加氢还原得4-三氟甲基苯胺,收率59.8%,纯度98.66%。然后,用硫酰氯作为氯化试剂,进行苯环上的氯化反应,制得氟虫腈关键中间体2,6-二氯-4-三氟甲基苯胺,收率83.9%,产品熔点34℃～35℃,纯度97.95%。对各步反应的影响因素进行了探讨。
4-Trifluoromethylaniline was synthesized by brominating 4-nitrotoluene, followed by fluorine substitution and hydrogenation, with a yield of 59.8% and a purity of 98.7%. Then, sulfonyl chloride was used as a chlorinating agent to chlorinate the benzene ring, resulting in 2,6-dichloro-4-trifluoromethylaniline, a key intermediate in production of fipronil. The yield and purity of 2,6-dichloro-4-trifluoromethylaniline were 83.9 and 98.0%, respectively, and the melting point was 34-35℃. The factors influencing all reaction steps are discussed.
出处
《农药》
CAS
北大核心
2006年第3期167-170,共4页
Agrochemicals
基金
浙江省教育厅科研项目(NO.20031087)
浙江省教育厅青年教师资助计划(2003)
