摘要
目的:探讨评估肾细胞癌预后因素的指标。方法:应用免疫组化方法对60例肾癌组织进行CD44v6和p16蛋白检测。结果:在肾癌细胞中CD44v6和p16蛋白表达阳性率分别为66.7%和51.7%。肾细胞癌分级、分期和淋巴结转移与CD44v6高表达和p16低表达相关(P<0.05);CD44v6表达与p16表达呈负相关(r=-0.43,P<0.01)。结论:CD44v6高表达和p16低表达,对判断肾细胞癌恶性程度、预测淋巴结转移有一定的参考价值。
Objective：To study the prognostic predictor for renal cell carcinoma. Methods：Immunohistochemical method were used to detect the expression of CD44v6 and p16 protein in 60 cases of renal cell carcinoma. Results： The positive rate of CD44v6 and p16 were 66.7% and 51.7% respectively. Histologic grading,elnieal staging and metastases potential of renal cell carcinoma were correlated with the high level expression of CD44v6 and the low level expression of p16 （ P 〈0.05）, respectively. The expression of CD44v6 was negativly correlated with the expression of p16（ P 〈0.01, γ = -0.43）. Conclusions： These results suggest that the high level expression of CD44v6 and the low level expression of p16 might be a good indicator in evaluating differentiation of tumors and in predicting lymph nodes metastases.
出处
《临床泌尿外科杂志》
2006年第1期45-46,48,共3页
Journal of Clinical Urology
