摘要
目的:研究卡托普利对失血性休克兔肠黏膜血流灌注的影响.方法:新西兰白兔30只随机分为空白对照组、失血性休克组、药物治疗组,通过Tonometry张力计测定并计算休克前(S0)、休克起点(S1)及再灌注1 h(REP1),再灌注2 h(REP2)乙状结肠pHi及Pi-aCO2,同时在上述时间点测定肠系膜静脉血乳酸浓度(Lac)、血氧饱和度(SvO2)及二氧化碳分压(PCO2).结果:休克组pHi(6.84±0.14)及肠系膜静脉血SvO2(44±7)%及PCO2(23.5±3.9)mmHg与对照组[分别为(7.31±0.06),(75±7)%,(40.4±0.8)mmHg]相比降低显著,肠系膜静脉乳酸值(3.62±0.32)mmol/L与对照组(1.49±0.72)mmol/L相比升高显著(P<0.01),尽管予以充分复苏,上述指标仍无明显改善;治疗组应用卡托普利后,肠黏膜的pHi(7.13±0.11)及肠系膜静脉血SvO2(66±6)%,PCO2(29.7±3.5)mmHg与休克组相比明显升高,肠系膜静脉血乳酸值(2.54±0.47)mmol/L明显下降(P<0.01).结论:卡托普利能大大改善失血性休克兔肠黏膜的血流灌注.
AIM ： To study the effect of captopril on gastrointestinal perfusion in hemorrhagic shocked rabbits. METHODS： Thirty rabbits were divided into 3 groups at random： normal control, shock group and therapeutic group, The shocked rabbits were treated with captopril 2.5 mg/kg at the beginning of the treatment. The animals＇ blood pressure was reduced to 5.3 kPa and maintained for 60 min. The rabbits were resuscitated at the beginning of treatment by reinfusing all of the shed blood. The values of sigmoid flexure pH （ pHi ） and Pi-aCO2 were calculated by using Henderson-Hasselbalch equation at S0, S1, 1 h reperfusion （ REP, ） and 2 h reperfusion （ REP2 ）. Lac, SvO2 and PCO2 of mesentery vein were determined at the same time. RESULTS： Although the rabbits in shock group were resuscitated completely compared with the normal control group, the flexure pH （ 6.84 ± 0.14）, SvO2 （44 ± 7 ） % and PCO2 （ 23.5 ± 3.9 ） mmHg of mesentery vein were much lower and Lac （ 3.62 ± 0.32 ） mmol/L of mesentery vein were much higher（P 〈 0.01 ）. But in the therapeutic group, Captopril dramatically improved the flexure pH （7. 13 ± 0.11） and SvO2（66±6）% and PCO2（29.7 ±3.5） mmHg of mesentery vein and decreased the Lac （ 2.54 ± 0. 47 ） mmol/L of mesentery vein, There was significant difference compared with those in shocked rabbits（ P 〈0.01 ）. CONCLUSION： Captopril can notably improve the gastrointestinal blood perfusion in hemorrhagic shocked rabbits.
出处
《第四军医大学学报》
北大核心
2006年第2期136-138,共3页
Journal of the Fourth Military Medical University
