摘要
目的探讨帕罗西汀合并小剂量曲唑酮对伴有勃起功能障碍(ED)抑郁症患者的疗效及安全性。方法将101例伴有勃起功能障碍的抑郁症患者随机分为研究组(50例)和对照组(51例),研究组在常规给予帕罗西汀治疗的基础上,合并小剂量曲唑酮,对照组仅给予帕罗西汀,疗程6周;于治疗前及治疗后1、2、4、6周采用汉密顿抑郁量表(HAMD)、勃起功能国际指数评分问卷(IIEF-5)及副反应量表(TESS)评定疗效、勃起功能及副反应。结果对抑郁症状的治疗,2组疗效相当,研究组显效率为86.0%,对照组为78.4%;但1周末及2周末研究组HAMD评分显著低于对照组(P<0.05)。对勃起功能,2组的显效率分别为56.0%、21.6%,差异具有显著性(P<0.01);研究组的IIEF-5评分于4周末即显著高于对照组;ED改善与HAMD阻滞因子减分值呈正相关。2组间TESS评分无显著性差异。结论帕罗西汀合并小剂量曲唑酮治疗抑郁症起效快,且可显著改善患者的勃起功能,安全性高。
Objective To explore the efficacy and safety of paroxetine with small-dose trazodone in the treatment of depression with erectile dysfunction. Methods 101 patients with the diagnosis of depression with erectile dysfunction were randomly divided into experimental group（ n=50）and control group（ n=51 ）. It was treated for paroxetine with small-dose trazodone in experimental group. The control group was treated with paroxetine for 6 weeks. The clinical efficacy, erectile function and side effects were evaluated with HAMD, IIEF-5 and TESS before treatment and 1,2,4,6 weeks after treatment respectively. Results In the treatment of depression symptoms, the significant improvement rate of experimental group was 86.0% , that of control group was 78.4%. There was no significant difference between two groups in efficacy. The scores of HAMD 1 and 2 weeks after treatment in the experimental group were significant lower than those in the control group（P〈0.05）. In the treatment of ED, the significant improvement rate of both groups was 56. 0% in experimental group and 21.6% in control group, respectively （ P 〈 0.01 ）. The scores of IIEF-5 from 4th week in the experimental group were significant higher than those in the control group. The improvement of ED was positively correlated with the reductive scores of retardation. But there was no difference in TESS between two groups. Conclusions Paroxetine with small-dose trazodone showed rapidly response in the treatment of depression symptom, and significantly improved the erectile dysfunction than paroxetine, and with less side effects.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2006年第1期39-42,共4页
Chinese Journal of Nervous and Mental Diseases
