摘要
caspase-10是近年来发现的一类含有死亡效应结构域(dead-effector domain,DED)的蛋白酶,在结构上与caspase家族的另一成员caspase-8有很高的同源性,通过形成死亡诱导信号复合物(death inducedsignaling complex,DISC),激活自身蛋白酶活性,传递凋亡信号。caspase-10的功能异常与许多疾病的发生有着密切的关系。对caspase-10的进一步研究将有助于深化对这些疾病的认识,并为临床治疗这些疾病提供新的方法和思路。
Caspase-10 is a dead-effector domain （DED）-containing protease and it is highly homologous to caspase-8, another important member of caspase family. By forming death induced signaling complex （DISC） , caspase-10 activates the protease itself, and then triggers the apoptotic pathway. The dysfunctional caspase-10 is highly correlated with the development of many diseases, such as tumor and autoimmune lymphoproliferative syndrome. The understanding of caspase-10 is of great importance for the treatment of many diseases in clinical practice.
出处
《医学分子生物学杂志》
CAS
CSCD
2006年第1期40-43,共4页
Journal of Medical Molecular Biology
基金
国家科技攻关计划项目子课题(No.2002BA711A01-13)~~
